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Molecular Mechanisms Controlling the Gene Expression Program for Corneal Repair

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Advances in Corneal Research

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Abstract

The wound healing response following surgical injury to the cornea can be quite variable and difficult to predict. The goal of this paper is to elucidate basic mechanisms which control activation of the corneal stromal cell to the repair phenotype and its subsequent competence to mediate repair tissue remodeling. These studies focused on expression of the matrix metalloproteinase, collagenase. The experiments performed in this study lead to the proposal of a new paradigm for understanding the modulation of repair gene expression by the wound environment, that is, regulation through autocrine cytokine intermediates. This model suggests a novel point at which drug intervention can be used to alter the repair process.

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Authors and Affiliations

  1. Developmental Biology Laboratory Vision Research Laboratories New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA

    M. Elizabeth Fini, Jeffery R. Cook, William B. Rinehart, Peter M. Sadow, Katherine J. Strissel & Judith A. West-Mays

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  1. M. Elizabeth Fini
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  2. Jeffery R. Cook
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  3. William B. Rinehart
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  4. Peter M. Sadow
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  5. Katherine J. Strissel
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  6. Judith A. West-Mays
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  1. Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio, USA

    Jonathan H. Lass

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Fini, M.E., Cook, J.R., Rinehart, W.B., Sadow, P.M., Strissel, K.J., West-Mays, J.A. (1997). Molecular Mechanisms Controlling the Gene Expression Program for Corneal Repair. In: Lass, J.H. (eds) Advances in Corneal Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5389-2_37

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  • DOI: https://doi.org/10.1007/978-1-4615-5389-2_37

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