Local Angiotensin II and Myocardial Fibrosis

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 432)


A wound healing response that eventuates in fibrous tissue formation appears at the site of myocardial infarction (MI). Fibrosis can also appear remote to the MI where it can cause an extensive structural remodeling of viable myocardium. Fibrosis, an abnormal increase in tissue collagen concentration, can adversely affect organ function.


Angiotensin Convert Enzyme Inhibitor Myocardial Fibrosis Infarcted Heart Collagen Gene Expression Binding Density 
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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Yao Sun
    • 1
  1. 1.Department of Internal MedicineUniversity of Missouri Health Sciences CenterColumbiaUSA

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