Left Ventricular Hypertrophy and Arterial Blood Pressure in Experimental Models of Hypertension
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Hypertensive left ventricular hypertrophy (LVH) is a major independent risk factor for cardiovascular morbidity and mortality in human essential hypertension. It has been shown that LVH is a better predictor of coronary artery disease and stroke than high blood pressure itself, hyperlipidaemia and cigarette smoking1,2. The spontaneously hypertensive rat (SHR) and its close relative stroke-prone SHR (SHRSP) have been used as models of hypertensive LVH and have allowed us to develop a number of mechanistic and genetic studies which would not have been feasible in human essential hypertension.
KeywordsLeft Ventricular Hypertrophy Cardiac Hypertrophy Heart Weight Body Weight Ratio Vascular Hypertrophy
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