Left Ventricular Hypertrophy and Arterial Blood Pressure in Experimental Models of Hypertension

  • A. F. Dominiczak
  • A. M. Devlin
  • M. J. Brosnan
  • N. H. Anderson
  • D. Graham
  • J. S. Clark
  • A. McPhaden
  • C. A. Hamilton
  • J. L. Reid
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 432)


Hypertensive left ventricular hypertrophy (LVH) is a major independent risk factor for cardiovascular morbidity and mortality in human essential hypertension. It has been shown that LVH is a better predictor of coronary artery disease and stroke than high blood pressure itself, hyperlipidaemia and cigarette smoking1,2. The spontaneously hypertensive rat (SHR) and its close relative stroke-prone SHR (SHRSP) have been used as models of hypertensive LVH and have allowed us to develop a number of mechanistic and genetic studies which would not have been feasible in human essential hypertension.


Left Ventricular Hypertrophy Cardiac Hypertrophy Heart Weight Body Weight Ratio Vascular Hypertrophy 
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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • A. F. Dominiczak
    • 1
  • A. M. Devlin
    • 1
  • M. J. Brosnan
    • 1
  • N. H. Anderson
    • 1
  • D. Graham
    • 1
  • J. S. Clark
    • 1
  • A. McPhaden
    • 1
  • C. A. Hamilton
    • 1
  • J. L. Reid
    • 1
  1. 1.Department of Medicine and TherapeuticsGardiner Institute Western InfirmaryGlasgowUK

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