Abstract
Hypertensive left ventricular hypertrophy (LVH) is a major independent risk factor for cardiovascular morbidity and mortality in human essential hypertension. It has been shown that LVH is a better predictor of coronary artery disease and stroke than high blood pressure itself, hyperlipidaemia and cigarette smoking1,2. The spontaneously hypertensive rat (SHR) and its close relative stroke-prone SHR (SHRSP) have been used as models of hypertensive LVH and have allowed us to develop a number of mechanistic and genetic studies which would not have been feasible in human essential hypertension.
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Dominiczak, A.F. et al. (1997). Left Ventricular Hypertrophy and Arterial Blood Pressure in Experimental Models of Hypertension. In: Zanchetti, A., Devereux, R.B., Hansson, L., Gorini, S. (eds) Hypertension and the Heart. Advances in Experimental Medicine and Biology, vol 432. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5385-4_3
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DOI: https://doi.org/10.1007/978-1-4615-5385-4_3
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