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Endothelial Dysfunction in Hypertensives

An Uncertain Association
  • P. A. van Zwieten
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 432)

Abstract

The experimental evidence for endothelial dysfunction associated with hypertensive disease appears impressive at first sight, and the relationship between both phenomena has been zealously defended by its protagonists (1–3).

Keywords

Endothelial Dysfunction Essential Hypertension Vasodilator Response Nitric Oxide Synthesis Hypertensive Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Vanhoutte PM, Boulanger CM. Endothelium-dependent responses in hypertension. Hypertens Res 1995; 18:87–98.PubMedCrossRefGoogle Scholar
  2. 2.
    Nava E, Lüscher TF. Endothelium-derived vasoactive factors in hypertension: Nitric oxide and endothelin. J Hypertens 1995;13(suppl 2):S39–S48.CrossRefGoogle Scholar
  3. 3.
    Lüscher TF. The endothelium in hypertension: Bystander, target or mediator? J Hypertens 1994; 12(suppl 10): S105–S116.Google Scholar
  4. 4.
    Ribeiro MO, Antunes E, de Nucci G, Lovisolo SM, Zatz R. Chronic inhibition of nitric oxide synthesis. A new model of arterial hypertension. Hypertension 1992;20:298–303.PubMedCrossRefGoogle Scholar
  5. 5.
    Baylis C, Mitruka B, Deng A. Chronic blockade of nitric oxide synthesis in the rat produces systemic hypertension and glomerular damage. J Clin Invest 1992;90:278–281.PubMedCrossRefGoogle Scholar
  6. 6.
    Chen PY, Sanders PW. L-arginine abrogates salt-sensitive hypertension in Dahl/Rapp rats. J Clin Invest 1991;88:1559–1567.PubMedCrossRefGoogle Scholar
  7. 7.
    Linder L, Kiowski W, Bühler FR, Lüscher TF. Indirect evidence for the release of endothelium-derived relaxing factor in the human forearm circulation in vivo: Blunted response in essential hypertension. Circulation 1990;81:1762–1767.PubMedCrossRefGoogle Scholar
  8. 8.
    Taddei S, Virdis A, Mattei P, Salvetti A. Vasodilatation to acetylcholine in primary and secondary forms of human hypertension. Hypertension 1993;21:929–933.PubMedCrossRefGoogle Scholar
  9. 9.
    Panza JA, Casino PR, Kilcoyne CM, Quyyumi AA. Impaired endothelium-dependent vasodilatation in patients with essential hypertension: Evidence that the abnormality is not at the muscarinic receptor level. J Am Coll Cardiol 1994;23:1610–1616.PubMedCrossRefGoogle Scholar
  10. 10.
    Panza JA, Garcia CE, Kilcoyne CM, Quyyumi AA, Cannon RO. Impaired endothelium-dependent vasodilatation in patients with essential hypertension: Evidence that nitric oxide abnormality is not localized to a single transduction pathway. Circulation 1995;91:1732–1738.PubMedCrossRefGoogle Scholar
  11. 11.
    Forte P, Copland M, Smith LM, Milne E, Sutherland J, Benjamin N. Basal nitric oxide synthesis in essential hypertension. Lancet 1997;349:837–842.PubMedCrossRefGoogle Scholar
  12. 12.
    Angus JA, Lew MJ. Interpretation of the acetylcholine test of endothelial cell dysfunction. J Hypertens 1992;10(suppl 7):S179–S186.Google Scholar
  13. 13.
    Hendriks MGC, Pfaffendorf M, van Zwieten PA. Characterization of the muscarinic receptors in the mesenteric vascular bed of spontaneously hypertensive rats. J Hypertens 1993; 11:1329–1335.PubMedCrossRefGoogle Scholar
  14. 14.
    Thybo NK, Mulvany MJ, Jastrup B, Nielsen H, Aalkjaer C. Some pharmacological and elastic characteristics of isolated small arteries from patients with essential hypertension. J Hypertens 1996;14:993–998.PubMedCrossRefGoogle Scholar
  15. 15.
    Laurent S, Lacolley P, Brunei P, Laloux B, Safar ME. Flow-dependent vasodilation of brachial artery in essential hypertension. Am J Physiol 1990; 258: H1004–H1011.PubMedGoogle Scholar
  16. 16.
    Girerd X, Arcaro G, Laurent S, Laloux B, Safar M. Study of flow-dependent vasodilation of the femoral artery in hypertensive and normotensive subjects. (In French.) Arch Mal Coeur Vaiss 1991;85:1075–1079.Google Scholar
  17. 17.
    Cockroft JR, Chowienczyck PJ, Ritter JM. Preserved endothelium-dependent vasodilation in patients with essential hypertension. N Engl J Med 1994;330:1036–1040.CrossRefGoogle Scholar
  18. 18.
    Bruning TA, Hendriks MGC, Chang PC, Kuypers EA, van Zwieten PA. In vivo characterization of vasodilating muscarinic-receptor subtypes in humans. Circ Res 1994;74:912–919.PubMedCrossRefGoogle Scholar
  19. 19.
    Bruning TA, Chang PC, Hendriks MGC, Vermeij P, Pfaffendorf M, van Zwieten PA. In vivo characterization of muscarinic receptor subtypes that mediate vasodilatation in patients with essential hypertension. Hypertension 1995;26:70–77.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • P. A. van Zwieten
    • 1
  1. 1.Departments of Pharmacotherapy, Cardiology, and Cardiopulmonary Surgery Academic Medical CenterUniversity of AmsterdamAmsterdamThe Netherlands

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