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Left Ventricular Hypertrophy, Arterial Compliance, and Aging

  • Mary J. Roman
  • Antonello Ganau
  • Pier Sergio Saba
  • Richard B. Devereux
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 432)

Abstract

An increase in arterial stiffness (or decrease in compliance) is a common feature of both the aging process1,2 and of hypertension3,4. The increase in vascular stiffness associated with aging is due to structural changes within the capacitance arteries resulting in an increase in pulse wave velocity, an alteration in arterial pressure waveform and the age-associated increase in systolic blood pressure1,5,6. In hypertension, the increase in vascular stiffness may simply reflect the increase in distending pressure, particularly when arterial stiffness is estimated using pressure-dependent indices3,7–9, but may also indicate an alteration in the physical properties of the vasculature due to structural changes attributable to hypertension per se 10. Although both hypertension and the aging process are associated with characteristic changes in left ventricular structure11,12, the extent to which vascular structural and functional alterations contribute, independently of blood pressure, to left ventricular remodelling is not well understood.

Keywords

Left Ventricular Hypertrophy Arterial Stiffness Pulse Wave Velocity Left Ventricular Mass Arterial Compliance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Hallock P. Arterial elasticity in man in relation to age as evaluated by the pulse wave velocity method. Arch Int Med 54:770 (1934)CrossRefGoogle Scholar
  2. 2.
    Avolio AP, Chen S, Wang R, Zhang C, Li M, O’Rourke MF. Effects of aging on changing arterial compliance and left ventricular load in a northern Chinese urban community. Circulation 68:50 (1983)PubMedCrossRefGoogle Scholar
  3. 3.
    Nichols WW, O’Rourke MF, Avolio AP, Yaginuma T, Pepine CJ, Conti CR. Ventricular/vascular interaction in patients with mild systemic hypertension and normal peripheral resistance. Circulation 74:455 (1986)PubMedCrossRefGoogle Scholar
  4. 4.
    Ting CT, Brin KP, Lin SJ, Wang SP, Chang MS, Chiang BN, Yin FCP. Arterial hemodynamics in human hypertension. J Clin Invest 78:1462 (1986)PubMedCrossRefGoogle Scholar
  5. 5.
    Murgo JP, Westerhof N, Giolma JP, Altobelli SA. Aortic input impedance in normal man: relationship to pressure wave forms. Circulation 62:105 (1980)PubMedCrossRefGoogle Scholar
  6. 6.
    Kelly R, Hayward C, Avolio A, O’Rourke M. Noninvasive determination of age-related changes in the human arterial pulse. Circulation 80:1652 (1989)PubMedCrossRefGoogle Scholar
  7. 7.
    Gribbin B, Pickering TG, Sleight P. Arterial distensibility in normal and hypertensive man. Clin Sci 56:413 (1979)PubMedGoogle Scholar
  8. 8.
    Roman MJ, Pini R, Pickering TG, Devereux RB: Non-invasive measurements of arterial compliance in hypertensive compared with normotensive adults. J Hypertens 10(Suppl 6):S115 (1992)Google Scholar
  9. 9.
    Hayoz D, Rutschmann B, Perret F, Niederberger M, Trady Y, Mooser V, Nussberger J, Waeber B, Brunner HR. Conduit artery compliance and distensibility are not necessarily reduced in hypertension Hypertension 20:1 (1992)PubMedCrossRefGoogle Scholar
  10. 10.
    Roman MJ, Saba PS, Pini R, Spitzer M, Pickering TG, Rosen S, Alderman MH, Devereux RB. Parallel cardiac and vascular adaptation in hypertension. Circulation 86:1909 (1992)PubMedCrossRefGoogle Scholar
  11. 11.
    Ganau A, Devereux RB, Roman M J, de Simone G, Pickering TG, Saba PS, Vargiu P, Simongini I, Laragh JH. Patterns of left ventricular hypertrophy and geometric remodelling in essential hypertension. J Am Coll Cardiol 19:1550 (1992)PubMedCrossRefGoogle Scholar
  12. 12.
    Ganau A, Saba PS, Roman MJ, de Simone G, Realdi G, Devereux RB. Ageing induces left ventricular concentric remodelling in normotensive subjects. J Hypertens 13:1818 (1995)PubMedCrossRefGoogle Scholar
  13. 13.
    Saba PS, Roman MJ, Pini R, Ganau A, Devereux RB. Relation of carotid pressure waveform to left ventricular anatomy in normotensive subjects. J Am Coll Cardiol 22:1873 (1993)PubMedCrossRefGoogle Scholar
  14. 14.
    Hayashi K, Handa H, Nagasawa S, Okumura A, Moritaki K. Stiffness and elastic behavior of human intracranial and extracranial arteries. J Biomechanics 13:175 (1980)CrossRefGoogle Scholar
  15. 15.
    Hirai T, Sasayma S, Kawasaki T, Yagi S. Stiffness of systemic arteries in patients with myocardial infarction. A noninvasive method to predict severity of coronary atherosclerosis. Circulation 80:78 (1989)Google Scholar
  16. 16.
    Laurent S, Hayoz D, Trazzi S, Boutouyrie P, Waeber B, Omboni S, Brunner HR, Mancia G, Safar M. Isobaric compliance of the radial artery is increased in patients with essential hypertension J Hypertens 11:89 (1993)PubMedCrossRefGoogle Scholar
  17. 17.
    Roman MJ, Pini R, Pickering TG, Devereux RB. Determinants of arterial stiffness in normotensive and hypertensive individuals. Circulation 90:1–506 (1994)CrossRefGoogle Scholar
  18. 18.
    Verdecchia P, Schillaci G, Borgioni C, Ciucci A, Battistelli M, Bartoccini C, Santucci A, Santucci C, Reboldi G, Porcellati C. Adverse prognostic significance of concentric remodeling of the left ventricle in hypertensive subjects with normal left ventricular mass. J Am Coll Cardiol 25:871 (1995)PubMedCrossRefGoogle Scholar
  19. 19.
    Ganau A, Devereux RB, Pickering TG, Roman MJ, Schnall PL, Santucci S, Spitzer MC, Laragh JH. Relation of left ventricular hemodynamic load and contractile performance to left ventriuclar mass in hypertension. Circulation 81:25 (1990)PubMedCrossRefGoogle Scholar
  20. 20.
    Roman MJ, Pickering TG, Pini R, Schwartz JE, Devereux RB. Prevalence and determinants of cardiac and vascular hypertrophy in hypertension. Hypertension 26:369 (1995)PubMedCrossRefGoogle Scholar
  21. 21.
    Hammond IW, Devereux RB, Alderman MH, Laragh JH. Relation of blood pressure and body build to left ventricular mass in normotensive and hypertensive employed adults. J Am Coll Cardiol 12:996 (1988)PubMedCrossRefGoogle Scholar
  22. 22.
    Roman MJ, Pickering TG, Schwartz JE, Pini R, Devereux RB. Differential impact of aging and hypertension on cardiac and vascular structure. Circulation 92:1–746 (1995)CrossRefGoogle Scholar
  23. 23.
    Heesen WF, Beltman FW, May JF, Smit AJ, de Graeff PA, Havinga TK, Schuurman FH, van der Veur E, Hamer JPM, Meyboom de-Jong B, Lie KJ. High prevalence of concentric remodeling in elderly individuals with isolated systolic hypertension from a population survey. Hypertension 29:539 (1997)PubMedCrossRefGoogle Scholar
  24. 24.
    Roman MJ, Pickering TG, Schwartz JE, Pini R, Devereux RB. Relation of arterial structure and function to left ventricular geometric patterns in hypertensive adults. J Am Coll Cardiol 28:751 (1996)PubMedCrossRefGoogle Scholar
  25. 25.
    Westerhof N, Sipkema P, van den Bos GC, Elzinga G. Forward and backward waves in the arterial system. Cardiovasc Res 6:648 (1972)PubMedCrossRefGoogle Scholar
  26. 26.
    O’Rourke MF, Yaginuma T. Wave reflection and the arterial pulse. Arch Intern Med 144:366 (1984)PubMedCrossRefGoogle Scholar
  27. 27.
    Kobayashi S, Yano M, Kohno M, Obayashi M, Hisamatsu Y, Ryoke T, Ohkusa T, Yamakawa K, Matsuzaki M. Influence of aortic impedance on the development of pressure-overload left ventricular hypertrophy in rats. Circulation 94:3362 (1996)PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Mary J. Roman
    • 1
  • Antonello Ganau
    • 2
  • Pier Sergio Saba
    • 2
  • Richard B. Devereux
    • 1
  1. 1.Division of CardiologyCornell University Medical CollegeNew YorkUSA
  2. 2.Istituto di Clinica MedicaUniversita di SassariSassariItaly

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