Left Ventricular Hypertrophy, Arterial Compliance, and Aging
- 91 Downloads
An increase in arterial stiffness (or decrease in compliance) is a common feature of both the aging process1,2 and of hypertension3,4. The increase in vascular stiffness associated with aging is due to structural changes within the capacitance arteries resulting in an increase in pulse wave velocity, an alteration in arterial pressure waveform and the age-associated increase in systolic blood pressure1,5,6. In hypertension, the increase in vascular stiffness may simply reflect the increase in distending pressure, particularly when arterial stiffness is estimated using pressure-dependent indices3,7–9, but may also indicate an alteration in the physical properties of the vasculature due to structural changes attributable to hypertension per se 10. Although both hypertension and the aging process are associated with characteristic changes in left ventricular structure11,12, the extent to which vascular structural and functional alterations contribute, independently of blood pressure, to left ventricular remodelling is not well understood.
KeywordsLeft Ventricular Hypertrophy Arterial Stiffness Pulse Wave Velocity Left Ventricular Mass Arterial Compliance
Unable to display preview. Download preview PDF.
- 8.Roman MJ, Pini R, Pickering TG, Devereux RB: Non-invasive measurements of arterial compliance in hypertensive compared with normotensive adults. J Hypertens 10(Suppl 6):S115 (1992)Google Scholar
- 15.Hirai T, Sasayma S, Kawasaki T, Yagi S. Stiffness of systemic arteries in patients with myocardial infarction. A noninvasive method to predict severity of coronary atherosclerosis. Circulation 80:78 (1989)Google Scholar
- 18.Verdecchia P, Schillaci G, Borgioni C, Ciucci A, Battistelli M, Bartoccini C, Santucci A, Santucci C, Reboldi G, Porcellati C. Adverse prognostic significance of concentric remodeling of the left ventricle in hypertensive subjects with normal left ventricular mass. J Am Coll Cardiol 25:871 (1995)PubMedCrossRefGoogle Scholar
- 23.Heesen WF, Beltman FW, May JF, Smit AJ, de Graeff PA, Havinga TK, Schuurman FH, van der Veur E, Hamer JPM, Meyboom de-Jong B, Lie KJ. High prevalence of concentric remodeling in elderly individuals with isolated systolic hypertension from a population survey. Hypertension 29:539 (1997)PubMedCrossRefGoogle Scholar