Left Ventricular Hypertrophy and Sympathetic Activity

  • Guido Grassi
  • Gino Seravalle
  • Giuseppe Mancia
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 432)


Pressure and/or volume overload has been regarded in the past as the leading mechanism through which an increase in blood pressure may trigger the development of left ventricular hypertrophy1. However, studies performed in recent years both in experimental animals and in man have suggested that not only mechanical but also sympathetic, genetic and hormonal factors (e.g. angiotensin II, insulin, thyroid hormones, etc) may significantly contribute to the development of the cardiac structural alterations frequently detected in the clinical course of the hypertensive state2,3.


Left Ventricular Hypertrophy Cardiac Hypertrophy Central Venous Pressure Plasma Renin Activity Lower Body Negative Pressure 
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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Guido Grassi
    • 1
    • 2
  • Gino Seravalle
    • 2
    • 3
  • Giuseppe Mancia
    • 1
    • 2
    • 3
  1. 1.Cattedra di Medicina Interna IOspedale S. GerardoMonzaItaly
  2. 2.Centro di Fisiologia Clinica e Ipertensione Ospedale Maggiore, IRCCSUniversità di MilanoMilanoItaly
  3. 3.IRCCSCentro Auxologico ItalianoMilanoItaly

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