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Left Ventricular Hypertrophy and Sympathetic Activity

  • Guido Grassi
  • Gino Seravalle
  • Giuseppe Mancia
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 432)

Abstract

Pressure and/or volume overload has been regarded in the past as the leading mechanism through which an increase in blood pressure may trigger the development of left ventricular hypertrophy1. However, studies performed in recent years both in experimental animals and in man have suggested that not only mechanical but also sympathetic, genetic and hormonal factors (e.g. angiotensin II, insulin, thyroid hormones, etc) may significantly contribute to the development of the cardiac structural alterations frequently detected in the clinical course of the hypertensive state2,3.

Keywords

Left Ventricular Hypertrophy Cardiac Hypertrophy Central Venous Pressure Plasma Renin Activity Lower Body Negative Pressure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    G. Evans. A contribution to the study of arteriosclerosis, with special reference to its relation to chronic disease. Q.J. Med. 1921;14:215–282.CrossRefGoogle Scholar
  2. 2.
    E.D. Frohlich and R.C. Tarazi. Is arterial pressure the sole factor responsible for hypertensive cardiac hypertrophy? Am J Cardiol. 1979;44:959–963.PubMedCrossRefGoogle Scholar
  3. 3.
    R.B. Devereux and M.J. Roman. Cardiac structure and function in hypertension. In A. Zanchetti, G. Mancia (eds) Handbook of Hypertension: vol.17 Pathophysiology of Hypertension. Elsevier Science, Amsterdam 1997:58–116.Google Scholar
  4. 4.
    G. Mancia, A. Ferrari, L. Gregorini, G. Leonetti, G. Parati, G.B. Picotti, C. Ravazzani and A. Zanchetti. Plasma catecholamines do not invariably reflect sympathetically induced changes in blood pressure in man. Clin Sci 1983;65:227–235.PubMedGoogle Scholar
  5. 5.
    G. Mancia, G. Grassi, G. Parati and A. Daffonchio. Evaluating sympathetic activity in human hypertension. J Hypertens 1993; 11(suppl 5):S13–S19.Google Scholar
  6. 6.
    D.S. Goldstein. Plasma catecholamines and essential hypertension: an analytical review. Hypertension 1983;5:86–99.PubMedCrossRefGoogle Scholar
  7. 7.
    M. Esler, G. Jackman, A. Bobik, D. Kelleker, G. Jennings, P. Leonard, H. Skews and P. Korner. Determination of norepinephrine apparent release rate and clearance in humans. Life Sci 1979;25:1461–1470.PubMedCrossRefGoogle Scholar
  8. 8.
    M. Esler, G. Lambert and G. Jennings. Regional norepinephrine turnover in human hypertension. Clin Exper Hypertens 1989;11(suppl 1):75–89.CrossRefGoogle Scholar
  9. 9.
    C. Ferrier, M. Esler, G. Eisenhofer, B.G. Wallin, M. Horne, H. Cox, G. Lambert and G. Jennings. Increased norepinephrine spillover into the cerebrovascular circulation in essential hypertension: Evidence of high central nervous system norepinephrine turnover? Hypertension 1992;19:62–69.PubMedCrossRefGoogle Scholar
  10. 10.
    A.B. Vallbo, K.E. Hagbarth, H.E. Torebjork and B.G. Wallin. Somatosensory, proprioceptive and sympathetic activity from peripheral nerves. Physiol Rev 1979;59:919–957.PubMedGoogle Scholar
  11. 11.
    G. Grassi, G.B. Bolla, G. Seravalle, C. Turri, A. Lanfranchi and G. Mancia. Comparison between reproducibility and sensitivity of muscle sympathetic nerve traffic and plasma noradrenaline in man. Clin Sci 1997; 92: 285–289.PubMedGoogle Scholar
  12. 12.
    Y. Yamada, E. Miyajima, O. Tochikubo, T. Matsukawa, H. Shionoiri, M. Ishii and Y. Kaneko. Impaired baroreflex changes in muscle sympathetic nerve activity in adolescents who have a family history of essential hypertension. J Hypertens 1988;6(suppl 4):S525–S528.Google Scholar
  13. 13.
    E.A. Anderson, C.A. Sinkey, W.J. Lawton and A.L. Mark. Elevated sympathetic nerve activity in borderline hypertensive humans: evidence from direct intraneural recording. Hypertension 1989;14:177–183.PubMedCrossRefGoogle Scholar
  14. 14.
    G. Mancia and G. Grassi. Baroreceptor control of the circulation in man. An update. Clin Exper Hypertens 1995;17:387–397.CrossRefGoogle Scholar
  15. 15.
    G. Grassi, G. Seravalle, A. Lanfranchi, S. Vailati, C. Turri, G.B. Bolla and G. Mancia. Sympathetic nerve traffic and baroreflex control of circulation in secondary hypertension. J Hypertens 1996; 14(suppl 1): 114 (abstract).Google Scholar
  16. 16.
    I. Östman-Smith. Cardiac sympathetic nerves as the final common pathway in the induction of adaptive cardiac hypertrophy. Clin Sci 1981;61:265–272.PubMedGoogle Scholar
  17. 17.
    R.C. Tarazi, S. Sen, M. Saragoca and P. Khairallah. The multifactorial role of catecholamines in hypertensive cardiac hypertrophy. Eur Heart J 1982;3(suppl A): 103–110.PubMedCrossRefGoogle Scholar
  18. 18.
    M.M. Laks, F. Morady and H.J.C. Swan. Myocardial hypertrophy produced by chronic infusion of subhypertensive doses of norepinephrine in the dog. Chest 1973;64:75–78.PubMedCrossRefGoogle Scholar
  19. 19.
    M.B. Patel, J.M. Stewart, A.V. Loud, P. Anversa, J. Wang, L. Fiegel and T.H. Hintze. Altered function and structure of the heart in dogs with chronic elevation in plasma norepinephrine. Circulation 1991;84:2091–2100.PubMedCrossRefGoogle Scholar
  20. 20.
    S. Sen, R.C. Tarazi, P. Khairallah and M. Bumpus. Cardiac hypertrophy in spontaneously hypertensive rats. Circ Res 1974;35:775–781.PubMedCrossRefGoogle Scholar
  21. 21.
    W. Zierhut and H.G. Zimmer. Significance of myocardial α-and β-adrenoceptors in catecholamine-induced cardiac hypertrophy. Circ Res 1989;65:1417–1425.PubMedCrossRefGoogle Scholar
  22. 22.
    E.D. Frohlich. Physiologic considerations in left ventricular hypertrophy. In F.H. Messerli (ed) The heart and hypertension. Yorke Medical Books, New York 1987: 43–52.Google Scholar
  23. 23.
    M. Esler, G. Lambert and G. Jennings. Increased regional sympathetic nervous activity in human hypertension: causes and consequences. J Hypertens 1990;8(suppl 7):S53–S57.Google Scholar
  24. 24.
    G. Mancia, R.R. Lorenz and J.T. Shepherd. Reflex control of circulation by heart and lungs. In: A.C. Guyton and A.W. Cowley (eds) Cardiovascular physiology II, vol 9. Baltimore, University Park Press 1976:111–144.Google Scholar
  25. 25.
    B.M. Egan, S. Julius, C. Cottier, K.J. Osterziel and H. Ibsen. Role of cardiovascular receptors on the neural regulation of renin release in normal man. Hypertension 1983;5:779–786.PubMedCrossRefGoogle Scholar
  26. 26.
    G. Grassi, C. Giannattasio, A. Saino, E. Sabadini, A. Capozi, L. Sampieri, C. Cuspidi and G. Mancia. Cardiopulmonary receptor modulation of plasma renin activity in normotensive and hypertensive subjects. Hypertension 1988;11:92–99.PubMedCrossRefGoogle Scholar
  27. 27.
    G. Grassi, C. Giannattasio, C. Cuspidi, G.B. Bolla, J. Cleroux, P. Ferrazzi, R. Fiocchi and G. Mancia. Cardiopulmonary receptor regulation of renin release. Am J Med 1988;84(suppl 3A):97–104.PubMedCrossRefGoogle Scholar
  28. 28.
    P.K. Mohanty, M.D. Thames, J.A. Arrowod, J.R. Sowers, C. McNamara and S. Szentpetery. Impairment of cardiopulmonary baroreflex after cardiac transplantation in humans. Circulation 1987;75:914–922.PubMedCrossRefGoogle Scholar
  29. 29.
    C. Giannattasio, A. Del Bo, B.M. Cattaneo, C. Cuspidi, E. Gronda, M. Frigerio, M. Mangiavacchi, M. Marabini, C. De Vita, G. Grassi, A. Zanchetti and G. Mancia. Reflex vasopressin and renin modulation by cardiac receptors in humans. Hypertension 1993;21:461–469.PubMedCrossRefGoogle Scholar
  30. 30.
    G. Grassi, C. Giannattasio, J. Cleroux, C. Cuspidi, L. Sampieri, G.B. Bolla and G. Mancia. Cardiopulmonary reflex before and after regression of left ventricular hypertrophy in essential hypertension. Hypertension 1988;12:227–237.PubMedCrossRefGoogle Scholar
  31. 31.
    A.L. Mark and G. Mancia. Cardiopulmonary baroreflexes in humans. In: J.T. Shepherd and F.M. Abboud (eds) Handbook of Physiology, sect 2, The cardiovascular system, Bethesda, Md, American Physiological Society 1983, vol III:795–813.Google Scholar
  32. 32.
    C. Giannattasio, G. Seravalle, G.B. Bolla, B.M. Cattaneo, J. Cleroux, C. Cuspidi, L. Sampieri, G. Grassi and G. Mancia. Cardiopulmonary receptor reflexes in normotensive athletes with cardiac hypertrophy. Circulation 1990;82:1222–1229.PubMedCrossRefGoogle Scholar
  33. 33.
    C. Giannattasio, G. Seravalle, B.M. Cattaneo, C. Cuspidi, L. Sampieri, G.B. Bolla, G. Grassi and G. Mancia. Effects of detraining on the cardiopulmonary reflex in professional runners and hammer throwers. Am J Cardiol 1992;69:677–680.PubMedCrossRefGoogle Scholar
  34. 34.
    G. Grassi and G. Mancia. Arterial baroreflexes and other cardiovascular reflexes in hypertension. In: J.D. Swales (ed): Textbook of Hypertension, Oxford, Blackwell Scientific Publications 1994:394–408.Google Scholar

Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Guido Grassi
    • 1
    • 2
  • Gino Seravalle
    • 2
    • 3
  • Giuseppe Mancia
    • 1
    • 2
    • 3
  1. 1.Cattedra di Medicina Interna IOspedale S. GerardoMonzaItaly
  2. 2.Centro di Fisiologia Clinica e Ipertensione Ospedale Maggiore, IRCCSUniversità di MilanoMilanoItaly
  3. 3.IRCCSCentro Auxologico ItalianoMilanoItaly

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