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The Renin-Angiotensin System Gene Polymorphism and Left Ventricular Hypertrophy

  • Laurence Tiret
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 432)

Abstract

Left ventricular hypertrophy (LVH) is a major risk factor for cardiovascular morbidity and mortality, independently of blood pressure. This has been clearly demonstrated in the Framingham Study. On the other hand, inhibitors of angiotensin-converting enzyme (ACE) have been shown to have a beneficial effect on LVH. In the SOLVD trial, treatment by ACE-inhibitors was associated with a reduction of the incidence of myocardial infarction (MI) and unstable angina and of cardiovascular mortality in patients with a low ejection fraction. In the SAVE trial including post-MI patients, treatment by ACE-inhibitors was associated with a decrease of mortality and incidence of re-infarction. These results, together with the fact that angiotensin II is implicated in the modulation of cardiac growth, suggest that polymorphisms of the renin angiotensin system could play a role in the determination of left ventricular mass (LVM) and the genetic predisposition of LVH.

Keywords

Left Ventricular Hypertrophy Left Ventricular Mass Hypertrophic Cardiomyopathy Renin Angiotensin System Idiopathic Dilate Cardiomyopathy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Laurence Tiret
    • 1
  1. 1.INSERMParisFrance

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