Advertisement

Volume Overload, Atrial Natriuretic Peptide, and Left Ventricular Hypertrophy

  • M. Luque Otero
  • N. Martell
  • A. L. Aubele
  • J. L. Rodrigo
  • M. Herrero
  • J. Moya
  • I. Egocheaga
  • A. Fernández-Cruz
  • C. Fernandez Pinilla
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 432)

Abstract

The development of high blood pressure leads to an increased hemodynamic afterload to the heart, wich is compensated by an increase of cardiac mass in order to maintain the cardiac output. However,despite the casual link between high blood pressure and left ventricular hypertrophy (LVH) clinical studies do not show a close correlation between blood pressure level and the degree of LVH (1).

Keywords

Cardiac Index Atrial Natriuretic Peptide Left Ventricular Mass Sodium Intake Total Peripheral Resistance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    R.B. Devereux, T.G. Pickering, M.H. Alderman, S. Chien, J.S. Borer and J.H. Laragh. Left ventricular hypertrophy in hypertension. Prevalence and relationship to pathophysiologic variables. Hypertension, 9(suppl II): II-53–II-60 (1987).Google Scholar
  2. 2.
    J.I.M. Drayer, M.A. Weber and J.L. Young. BP as a determinant of cardiac left ventricular muscle mass. Arch Intern Med, 143: 90–92 (1983).PubMedCrossRefGoogle Scholar
  3. 3.
    R.B. Devereux. Detection of left ventricular hypertrophy by M-mode echocardiography. Anatomic validation, standardization and comparison to other methods. Hypertension, 9(suppl II): II-19–II-26 (1987).Google Scholar
  4. 4.
    L. M. Prisant, D.J. Kleinman, A.A. Carr, P.B. Bottini and C.M. Gross. Assessment of echocardiographic left ventricular mass before and after acute volume depletion. Am J Hypertens, 7: 425–428 (1994).PubMedGoogle Scholar
  5. 5.
    F.H. Messerli, K. Sungaard-Ruse, H.O. Ventura, F.G. Dunn, W. Oigmann and E.D. Frohlich. Clinical and hemodynamic determinants of left ventricular dimensions. Arch Intern Med, 144: 477–482 (1984).PubMedCrossRefGoogle Scholar
  6. 6.
    R.E. Schmieder, F.H. Messerli, G.E. Garavaglia and B.D. Nunez. Dietary salt intake. A determinant of cardiac involvement in essential hypertension. Circulation, 78: 951–956 (1988).PubMedCrossRefGoogle Scholar
  7. 7.
    N. Martell, J.L. Rodrigo, C. Fernandez-Pinilla, J. Gutkowska, A. Fernandez-Cruz, F. Vivas, M.C. Ramon, M.J. Pascual and M. Luque-Otero. Sodium intake and atrial natriuretic factor as determinants of left ventricular dimensions: the Torrejon Study. J Hypertens, 9(suppl 6): s258–s259 (1991).Google Scholar
  8. 8.
    G.A. Sagnella, N.D. Markandu, A.C. Shore and G.A. MacGregor. Changes in plasma immunoreactive atrial natriuretic peptide in response to saline infusion or to alterations in dietary sodium intake in normal subjects. J Hypertens, 4(suppl 2): s115–s118 (1986).Google Scholar
  9. 9.
    R.B. Devereux, D.D. Savage, I. Sachs and J.H. Laragh. Relation of hemodynamic load to left ventricular hypertrophy and performance in hypertension. Am J Cardiol, 51: 171–176 (1983).PubMedCrossRefGoogle Scholar
  10. 10.
    F. Abi-Samra, F.M. Fouad and R.C. Tarazi. Determinants of left ventricular hypertrophy and function in hypertensive patients: an echocardiographic study. Am J Med, 75(suppl 3A): 26–33 (1983).PubMedCrossRefGoogle Scholar
  11. 11.
    G. de Simone, L. DiLorenzo, G. Costantino, D. Moccia, S. Buonissimo and O. de Vittiis. Hemodynamic hypertrophied left ventricular patterns in systemic hypertension. Am J Cardiol, 60: 1317–1321 (1987).PubMedCrossRefGoogle Scholar
  12. 12.
    M. Luque Otero, J.L. Rodrigo, J. Alcazar, R. Gabriel, C. Fernandez Pinilla, A. Fernandez-Cruz and N. Martell Claros. Hemodynamic in children with blood pressures in the 95th percentile of the distribution. J Hypertens, 5(suppl 5): s435–s437 (1987).Google Scholar
  13. 13.
    R.C. Tarazi, M.M. Ibrahim, H.P. Dustam and C.M. Ferrario. Cardiac factors in hypertension. Circ Res, 34(suppl I): I-213–I-221 (1974).Google Scholar
  14. 14.
    M.M. Ibrahim, R.C. Tarazi, H.P. Dustan, E.L. Bravo, R.W. Gifford Jr. Hyperkinetic heart in severe hypertension: a separate clinical hemodynamic entity. Am J Cardiol, 35:667–674 (1975).PubMedCrossRefGoogle Scholar
  15. 15.
    A. Ganau, R.B. Devereux, M.J. Roman, G. de Simone, T.G. Pickering, P.S. Saba, P. Vargiu, Y. Simongini and J.H. Laragh. Patterns of left ventricular hypertrophy and geometric remodeling in essential hypertension. J Am Coll Cardiol, 19: 1550–1558 (1992).PubMedCrossRefGoogle Scholar
  16. 16.
    M.J. Koren, R.B. Devereux, P.N. Casale, D.D. Savage and J.H. Laragh. Relation of left ventricular mass and geometry to morbidity and mortality in uncomplicated essential hypertension. Ann Intern Med, 114: 345–352 (1991).PubMedGoogle Scholar
  17. 17.
    Y. Shigematsu, M. Hamada, M. Mukai, H. Matsuoka, T. Sumimoto and K. Hiwada. Clinical evidence for an association between left ventricular geometric adaptation and extracardiac target organ damage in essential hypertension, J Hypertens, 13: 155–160 (1995).PubMedCrossRefGoogle Scholar
  18. 18.
    B.E. Strauer. Hypertensive Heart Disease. Berlin: Springer-Verlag. 1980.CrossRefGoogle Scholar
  19. 19.
    C.J. Lavie and F.H. Messerli. Cardiovascular adaptation to obesity and hypertension. Chest, 90: 275–279 (1986).PubMedCrossRefGoogle Scholar
  20. 20.
    A. Ganau, A. Arru, P.S. Saba G. Piga, N. Glorioso, G. Tonolo, G. Madeddu and G. Bianchi. Stroke volume and left heart anatomy in relation to plasma volume in essential hypertension. J Hypertens, 9(suppl 6): s150–s151 (1991).Google Scholar
  21. 21.
    M.A. Fitzpatrick, A.L. Hinderliter, B.M. Egan, S. Julius. Decreased venous distensibility and reduced renin responsiveness in hypertension. Hypertension, 8(suppl II): II-36–II-43 (1986).Google Scholar

Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • M. Luque Otero
    • 1
  • N. Martell
    • 1
  • A. L. Aubele
    • 1
    • 2
  • J. L. Rodrigo
    • 1
    • 2
  • M. Herrero
    • 1
  • J. Moya
    • 1
  • I. Egocheaga
    • 1
  • A. Fernández-Cruz
    • 1
  • C. Fernandez Pinilla
    • 1
  1. 1.Hypertension UnitHospital Universitario San Carlos Universidad ComplutenseMadridSpain
  2. 2.Departamento de Exploración CardiopulmonarHospital Universitario San Carlos Universidad ComplutenseMadridSpain

Personalised recommendations