Relations of Left Ventricular Geometry and Function to Prognosis in Hypertension

  • Richard B. DevereuxEmail author
  • Giovanni de Simone
  • Mary J. Roman
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 432)


The heart plays a central role in systemic hypertension, since it both generates the increased force needed to sustain elevated arterial blood pressure and suffers the morbid consequences thereof. The importance of left ventricular (LV) hypertrophy as a cardinal manifestation of hypertensive target organ damage was first suspected based on the ability of ECG LV hypertrophy to predict morbidity and mortality in patients with hypertension,1–3 in the general population,4–5 and in catheterized patients with or without coronary artery obstruction.6 However, it was uncertain whether these patterns derived their significance from cardiac hypertrophy or from ECG manifestations of myocardial ischemia. This uncertainty has been resolved by the demonstration that increased LV mass is a potent predictor of cardiovascular morbidity and mortality, independent of age, gender, blood pressure or other risk factors.7–19 It is the purpose of this chapter to review available evidence concerning: 1) the relation of LV hypertrophy to prognosis; 2) whether additional consideration of LV geometric patterns further aids risk stratification; 3) the relation between LV myocardial function and prognosis; 4) potential mechanisms of observed relations between LV muscle mass and function on, the one hand, and morbid events due to vascular thrombosis, on the other; and 5) available evidence concerning the possible prognostic benefit of LV hypertrophy regression.


Left Ventricular Hypertrophy Left Ventricular Mass Coronary Flow Reserve Normal Left Ventricular Morbid Event 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Richard B. Devereux
    • 1
    Email author
  • Giovanni de Simone
    • 1
  • Mary J. Roman
    • 1
  1. 1.Department of MedicineNew York Hospital, Cornell Medical CenterNew YorkUSA

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