The Role of N-Linked Glycosylation in the Secretion of Hepatitis B Virus

  • Anand Mehta
  • Timothy M. Block
  • Raymond A. Dwek
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 435)


Hepatitis B virus (HBV) is the human member of the hepadnaviradae family of viruses which chronically infects over 300 million people worldwide. Infection by HBV can lead to both acute and chronic liver disease. For those unfortunate to become chronic carriers of HBV, there are lifelong complication associated with the virus. Indeed up to 40% of chronic carriers may eventually develop hepatocellular carcinoma (1). As there is such a large pool of chronic carriers, it can be assumed that a vast number of the worlds population die from complications that arise from infection with HBV.


Glycan Structure Chronic Carrier Glycan Site Glycan Processing 
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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Anand Mehta
    • 1
  • Timothy M. Block
    • 2
  • Raymond A. Dwek
    • 1
  1. 1.The Glycobiology Institute, Department of BiochemistryOxford UniversityOxfordUK
  2. 2.Viral Hepatitis Group, Kimmel Cancer CenterJefferson Medical CollegePhiladelphiaUSA

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