IgA Glycosylation in IgA Nephropathy
IgA nephropathy (IgAN) is the commonest form of glomerulonephritis in developed countries where renal biopsy is widely practiced1. IgAN is defined by the deposition of IgA in the glomerular mesangium. Most typically, patients present with episodes of visible haematuria, which often concide with respiratory or gastrointestinal infection. At this early stage renal function may be preserved but slowly progressive renal failure is common. Up to 30% of patients with IgAN will require renal replacement therapy by dialysis or transplantation within 20 years of presentation2. Since IgAN is characteristically diagnosed in children and young adults, many of these patients will develop renal failure in young or middle age. The formidable personal, social and financial implications of renal failure emphasise the importance of investigating fundamental pathogenic processes in IgAN with the long term aim of interrupting disease progression.
KeywordsHinge Region Lectin Binding Asialoglycoprotein Receptor Vicia Villosa Lower Molecular Weight Band
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