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IgA Glycosylation in IgA Nephropathy

  • Alice Allen
  • John Feehally
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 435)

Abstract

IgA nephropathy (IgAN) is the commonest form of glomerulonephritis in developed countries where renal biopsy is widely practiced1. IgAN is defined by the deposition of IgA in the glomerular mesangium. Most typically, patients present with episodes of visible haematuria, which often concide with respiratory or gastrointestinal infection. At this early stage renal function may be preserved but slowly progressive renal failure is common. Up to 30% of patients with IgAN will require renal replacement therapy by dialysis or transplantation within 20 years of presentation2. Since IgAN is characteristically diagnosed in children and young adults, many of these patients will develop renal failure in young or middle age. The formidable personal, social and financial implications of renal failure emphasise the importance of investigating fundamental pathogenic processes in IgAN with the long term aim of interrupting disease progression.

Keywords

Hinge Region Lectin Binding Asialoglycoprotein Receptor Vicia Villosa Lower Molecular Weight Band 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Alice Allen
    • 1
  • John Feehally
    • 1
  1. 1.Department of NephrologyLeicester General HospitalLeicesterUK

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