Glycosylation and Rheumatic Disease

  • John S. Axford
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 435)


Oligosaccharide biochemistry has been an important field of research for many years and this area of basic science continues to flourish.


Rheumatoid Arthritis High Performance Liquid Chromatography Rheumatic Disease Rheumatoid Factor Rheumatoid Arthritis Group 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Dwek RA. Glycobiology: Towards undertanding the function of sugars. (Wellcome Trust Award Lecture 1994) Biochemical Society Transactions 23 1995Google Scholar
  2. 2.
    Feizi T. Demonstration by monoclonal antibodies that carbohydrate structures of glycoproteins and glycolipids are onco-developmental antigens. Nature 1985; 314: 53–57.PubMedCrossRefGoogle Scholar
  3. 3.
    Crocker PR & Feizi T. Carbohydrate recognition systems: functional triads in cell-cell interactions. Curr Opin. Structur Biol 1996 (In Press).Google Scholar
  4. 4.
    Axford JS et al (1992) Second Jenner International Glycoimmunology Meeting. Ann Rheum Dis 1269–1285.Google Scholar
  5. 5.
    Axford JS et al (1994) Third Jenner International Glycoimmunology Meeting. Glycosylation & Dis 3:197–227.Google Scholar
  6. 6.
    Axford JS (1993) Trends. Second Jenner International Glycoimmunology Meeting Immunology Today 14(3): 104–106.Google Scholar
  7. 7.
    Axford JS (1995) Trends. Third Jenner International Glycoimmunology Meeting Immunology Today 16(5): 213–215.Google Scholar
  8. 8.
    Axford JS (1991 ) Oligosaccharides: An optional extra or of relevance to disease mechanisms in rheumatology? J Rheumatol 18(8): 1124–1127.PubMedGoogle Scholar
  9. 9.
    Axford JS (1994) Glycosylation and rheumatic disease: more than icing on the cake. J Rheumatol 21(10): 1791–1795.PubMedGoogle Scholar
  10. 10.
    Alavi A & Axford JS (1996) Chapter: The glycosytransferases from abnormalities of IgG glycosylation and immunological disorders. Edited by Isenberg DA & Rademacher TW. Published by John Wiley & Sons.Google Scholar
  11. 11.
    Alavi A & Axford JS. Glycoimmunology. Published by Plenum Publishing Co. Ltd 1995.Google Scholar
  12. 12.
    Varki A. Biological roles of oligosaccharides: all of the theories are correct. Glycobiology 1993;3(2): 97–130.PubMedCrossRefGoogle Scholar
  13. 13.
    Feizi T. Oligosaccharides that mediate mammalian cell-cell adhesion. Curr Opin. Struct Biol. 1993;3:701–710.CrossRefGoogle Scholar
  14. 14.
    Hagopian A & Eylar EH. Glycoprotein biosynthesis: studies on the receptor specificity of the polypeptide: N-acetylgalactosaminyl-transferase from bovine submaxillary glands. Arch. Biochem Biophys 1968; 128(2): 422–433.PubMedCrossRefGoogle Scholar
  15. 15.
    Farquhar MG & Palade G. The Golgi apparatus (complex) — (1954–81) from artifact to center stage. J Cell Biol 1981; 91(3): 77–103.CrossRefGoogle Scholar
  16. 16.
    Roth J & Berger EG. Immunocytochemical localisation of galactosyltransferase in HeLa cells: co-distribution with thiamine pyrophosphatase in trans-Golgi cisternae. J Cell Biol 1982;93(1): 223–229.PubMedCrossRefGoogle Scholar
  17. 17.
    Roth J. Taatjes DJ, Lucocq JM, Weinstein J, Paulson JC. Demonstration of an extensive trans-tubular network continuous with the Golgi apparatus stack that may function in glycosylation. Cell 1985;43(1): 287–295.PubMedCrossRefGoogle Scholar
  18. 18.
    Rabouille C, Hui N, Hunte F, Kieckbusch R, Berger EG, Warren G, Nilsson T. Mapping the distribution of Golgi enzymes involved in the construction of complex oligosaccharides. J Cell Sci. 1995;108(4): 1617–1627.PubMedGoogle Scholar
  19. 19.
    Roseman S. The synthesis of complex carbohydrates by multi-glycosyltransferase systems and their potential function in intercellular adhesion. Chem Phys Lipids 1970; 5(1): 270–297.PubMedCrossRefGoogle Scholar
  20. 20.
    Nilsson T & Warren G. Retention and retrieval in the endoplasmic reticulum and the Golgi apparatus. Curr Opin Cell Biol 1994;6(4): 517–521.PubMedCrossRefGoogle Scholar
  21. 21.
    Berger EG & Thurnher M. Clues to the cell-specific synthesis of complex carbohydrates. News Physiol Sci. 1993;8: 57–60.Google Scholar
  22. 22.
    Berger EG, M Thurnher and U Muller. Galactosyltransferase and sialyltransferase are located in different subcellular compartments in HeLa cells. Exp Cel Res (EPB) 1987; 173: 267–73.CrossRefGoogle Scholar
  23. 23.
    Shur BD and S Roth. Cell surface glycosytransferases. Biochim Biophys Acta 1975;415: 473–512.PubMedCrossRefGoogle Scholar
  24. 24.
    Schachter H and L Rodén. The biosynthesis of animal glycoproteins. In: Metabolic Conjugation and Metabolic Hydrolysis; WH Fishman, Editor; Academic Press, New York, pp 1–149.Google Scholar
  25. 25.
    McGuire EJ, R Kerlin, JJ Cebra and S Roth. A human milk galactosyltyransferase is specific for secreted, but not plasma IgA. J Immunol 1989;143(9): 2933–8.PubMedGoogle Scholar
  26. 26.
    Shaper NL, JH Shaper, V Bertness, H Chang, IR Kirsch and Hollis GF. The human galactosyltransferase gene is on chromosome 9 at band p13. Somatic Cell Mol Genet 1986; 12Google Scholar
  27. 27.
    Russo RN, NL Shaper and JH Shaper. Bovine β 1,4 galactosyltransferase: two sets of mRNA transcripts encode two forms of the protein with different amino-terminal domains. In vitro translation experiments demonstrate that both the short and the long forms of the enzyme are type II membrane-bound glycoproteins. J Biol Chem 1990;265(6): 3324–31.PubMedGoogle Scholar
  28. 28.
    Shur, BD, and NG Hall. Sperm surface galactosyltransferase activities during in vitro compaction. J Cell Biol 1982;95: 567–573.PubMedCrossRefGoogle Scholar
  29. 29.
    Bayna EM, RB Runyan, NF Scully, J Reichner, LC Lopez and BD Shur. Cell surface galactosyltransferase as a recognition molecule during development. Mol Cell Biochem 1986;72:141–51.PubMedCrossRefGoogle Scholar
  30. 30.
    Bayna ME, JH Shaper and BD Shur. Temporally specific involvement of cell surface β-1,4 galactosyltransferase during mouse embryo morula compaction. Cell 1988;53: 145–157.PubMedCrossRefGoogle Scholar
  31. 31.
    Begovac PC and BD Shur. Cell surface galactosyltransferase mediates the initiation of neutite outgrowth from PC12 cells on laminin. J Biol Chem 1990;110(2): 461–70.Google Scholar
  32. 32.
    Parekh RB, Dwek RA, Sutton BJ etl al. Association of rheumatoid arthritis and primary osteoarthritis with changes in the glycosylation pattern of total serum IgG. Nature 1985;316:452–457.PubMedCrossRefGoogle Scholar
  33. 33.
    Axford JS. Medicine Published by Blackwell Science 1996.Google Scholar
  34. 34.
    Soltys AJ, Hay FC, Bond A, Axford JS, Jones MG, Randen I, Thompson K & Natvig J. The binding of synovial tissue-derived human monoclonal immunoglobulin M rheumatoid factor to immunoglobulin G preparations of differing galactose content. Scan J Immunol 40(2): 135–143 (1994).CrossRefGoogle Scholar
  35. 35.
    Axford JS, Sumar N, Alavi A, Isenberg DA, Young A, Bodman KB, Roitt IM. Changes in normal glycosylation mechanisms in autoimmune rheumatic disease. J Clin Invest 89(3): 1021–1031 (1992).PubMedCrossRefGoogle Scholar
  36. 36.
    Pool AJ, Alavi A & Axford JS. β 1,4-galactosytransferase isoenzyme changes in serum of patients with rheumatoid arthritis. Br J Rheumatol 35(1) Suppl. 174 No.335 (1996).Google Scholar
  37. 37.
    Bond A, Alavi A, Axford JS, Youinou P & Hay FC. The relationship between exposed galactose and N-acetylglucosamine residues on IgG in RA, JCA and Sjögren’s syndrome. Clin Exp. Immunol 105: 99–103 (1996).PubMedCrossRefGoogle Scholar
  38. 38.
    Watson M, Rudd P, Dwek RA & Axford JS. Sugar printing rheumatic diseases: A potential method for diagnosis and differentiation using immunoglobulin G oligosaccharides. Arth Rheum 39(9) Suppl. S216 No. 1133 (1996).Google Scholar

Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • John S. Axford
    • 1
  1. 1.Academic Rheumatology UnitSt. George’s Hospital Medical SchoolLondonUK

Personalised recommendations