Occurrence and Possible Function of Inflammation-Induced Expression of Sialyl Lewis-X on Acute-Phase Proteins

  • Willem Van Dijk
  • Els C. M. Brinkman-Van der Linden
  • Ellen C. Havenaar
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 435)


The complex-type glycan structures of acute-phase glycoproteins (APPs) are subject to marked changes during acute and chronic inflammation (see for review Van Dijk et al., 1994). In vivo studies with mice transgenic for human α1,-acid glycoprotein (AGP) and in vitro studies with human hepatoma cell lines (Mackiewicz et al., 1991) and isolated human and rat hepatocytes (Pos et al., 1988; Pos et al. 1989; Van Dijk et al., 1991a; Van Dijk et al. 1991b) have indicated that these changes are not simply determined by changes in serum concentration or in secretion rates of acute-phase glycoproteins. The biosynthesis of the glycans in the hepatocytes of the liver appeared to be affected as part of the hepatic acute-phase reaction. Inflammatory cytokines, like IL-6 and IL-lα, and glucocorticoids are involved in the regulation of these processes.


Bovine Colostrum Fucose Residue Aleuria Aurantia Lectin Affinity Electrophoresis sLeX Expression 
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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Willem Van Dijk
    • 1
  • Els C. M. Brinkman-Van der Linden
    • 1
  • Ellen C. Havenaar
    • 1
  1. 1.Department of Medical Chemistry Faculty of MedicineVrije UniversiteitAmsterdamThe Netherlands

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