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Occurrence and Possible Function of Inflammation-Induced Expression of Sialyl Lewis-X on Acute-Phase Proteins

  • Willem Van Dijk
  • Els C. M. Brinkman-Van der Linden
  • Ellen C. Havenaar
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 435)

Abstract

The complex-type glycan structures of acute-phase glycoproteins (APPs) are subject to marked changes during acute and chronic inflammation (see for review Van Dijk et al., 1994). In vivo studies with mice transgenic for human α1,-acid glycoprotein (AGP) and in vitro studies with human hepatoma cell lines (Mackiewicz et al., 1991) and isolated human and rat hepatocytes (Pos et al., 1988; Pos et al. 1989; Van Dijk et al., 1991a; Van Dijk et al. 1991b) have indicated that these changes are not simply determined by changes in serum concentration or in secretion rates of acute-phase glycoproteins. The biosynthesis of the glycans in the hepatocytes of the liver appeared to be affected as part of the hepatic acute-phase reaction. Inflammatory cytokines, like IL-6 and IL-lα, and glucocorticoids are involved in the regulation of these processes.

Keywords

Bovine Colostrum Fucose Residue Aleuria Aurantia Lectin Affinity Electrophoresis sLeX Expression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Willem Van Dijk
    • 1
  • Els C. M. Brinkman-Van der Linden
    • 1
  • Ellen C. Havenaar
    • 1
  1. 1.Department of Medical Chemistry Faculty of MedicineVrije UniversiteitAmsterdamThe Netherlands

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