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cellulomonas sp. Purine Nucleoside Phosphorylase (PNP)

Comparison with Human and E. coli Enzymes

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Purine and Pyrimidine Metabolism in Man IX

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 431))

Abstract

The ubiquitous enzyme purine nucleoside phosphorylase (PNP, E.C. 2.4.2.1.) catalyzes the reversible phosphorolysis of naturally occurring purine nucleosides, and many analogues, as follows:

$$\beta {\rm{ - purine}}\,{\rm{nucleoside}}\,{\rm{ + }}\,{\rm{orthophosphate}}\, \Leftrightarrow \,{\rm{purine}} + \alpha {\rm{ - D - pentose - }}1{\rm{ - phosphate}}$$

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Authors and Affiliations

  1. Department of Biophysics Institute of Experimental Physics, University of Warsaw, Zwirki i Wigury 93, 02-089, Warsaw, Poland

    Beata Wielgus-Kutrowska, Agnieszka Bzowska & David Shugar

  2. Institut für Kristallographie, Freie Universität Berlin, Takustr. 6, D-14195, Berlin, Germany

    Jan Tebbe, Wolfram Saenger & Gertraud Koellner

  3. Institut für Biochemie, Freie Universität Berlin, Thielallee 63, D-14195, Berlin, Germany

    Werner Schröder

  4. Rudjer Boskovic Institute, Bijenicka 54, 10000, Zagreb, Croatia

    Marija Luic

Authors
  1. Beata Wielgus-Kutrowska
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  2. Agnieszka Bzowska
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  3. David Shugar
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  4. Jan Tebbe
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  5. Wolfram Saenger
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  6. Gertraud Koellner
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  7. Werner Schröder
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  8. Marija Luic
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Editor information

Editors and Affiliations

  1. Emperor Franz Joseph Hospital, Vienna, Austria

    Andrea Griesmacher  & Mathias M. Müller  & 

  2. University of Vienna, Vienna, Austria

    Peter Chiba

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© 1998 Springer Science+Business Media New York

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Wielgus-Kutrowska, B. et al. (1998). cellulomonas sp. Purine Nucleoside Phosphorylase (PNP). In: Griesmacher, A., Müller, M.M., Chiba, P. (eds) Purine and Pyrimidine Metabolism in Man IX. Advances in Experimental Medicine and Biology, vol 431. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5381-6_51

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  • DOI: https://doi.org/10.1007/978-1-4615-5381-6_51

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7456-5

  • Online ISBN: 978-1-4615-5381-6

  • eBook Packages: Springer Book Archive

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