Abstract
Adenosine is an ubiquitous nucleoside that mediates several important physiological effects, trough the binding of three pharmacologically distinct receptor subtypes, named A1 A2 and A 3 .1 Adenosine receptor subtypes has been distinguished on the basis of the effect of adenosine on the cellular content of cAMP: occupancy of A2 adenosine receptors induces an increase in cAMP level in several cells types, by contrast stimulation of A 1 receptors causes the opposite effect. These effects are mediated by a coupling of these receptor subtypes with Gs and Gi transduction-proteins, respectively.2
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Martini, C. et al. (1998). A1 Adenosine Receptors in Human Neutrophils. In: Griesmacher, A., Müller, M.M., Chiba, P. (eds) Purine and Pyrimidine Metabolism in Man IX. Advances in Experimental Medicine and Biology, vol 431. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5381-6_21
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DOI: https://doi.org/10.1007/978-1-4615-5381-6_21
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