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Cardiovascular Actions of Adenosine

Granulocyte and Blood Platelet Adhesion in the Reperfused Myocardium

  • Chapter
Purine and Pyrimidine Metabolism in Man IX

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 431))

Abstract

Adenosine is a pluripotent bioactive metabolite, long known to be formed and released from ischemic and reperfused myocardium owing to enhanced catabolism of adenine nucleotides under these conditions.2,6,16 However, beyond its familiar dilatory actions on coronary and peripheral vessels and its bradyarrhythmic potential in the heart, adenosine also exerts potent effects on the intracoronary adhesion of leukocytes and blood platelets and may be involved in the phenomenon of ischemic preconditioning.3–810,23,33 Table 1 summarizes these actions according to the type of membrane receptor presumably involved, 4 kinds—designated Al, A2a, A2b and A3—having been pharmacologically characterized and cloned to date.23

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Authors and Affiliations

  1. Department of Physiology, University of Munich, Pettenkoferstr. 12, 80336, Munich, Germany

    B. F. Becker, S. Zahler, C. Kupatt, C. Seligmann, B. Heindl & C. Kowalski

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  1. B. F. Becker
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  2. S. Zahler
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  3. C. Kupatt
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  4. C. Seligmann
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  5. B. Heindl
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  6. C. Kowalski
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Editors and Affiliations

  1. Emperor Franz Joseph Hospital, Vienna, Austria

    Andrea Griesmacher  & Mathias M. Müller  & 

  2. University of Vienna, Vienna, Austria

    Peter Chiba

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Becker, B.F., Zahler, S., Kupatt, C., Seligmann, C., Heindl, B., Kowalski, C. (1998). Cardiovascular Actions of Adenosine. In: Griesmacher, A., Müller, M.M., Chiba, P. (eds) Purine and Pyrimidine Metabolism in Man IX. Advances in Experimental Medicine and Biology, vol 431. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5381-6_14

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  • DOI: https://doi.org/10.1007/978-1-4615-5381-6_14

  • Publisher Name: Springer, Boston, MA

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  • Online ISBN: 978-1-4615-5381-6

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