Summary
We measured the serum concentrations of l,25(OH)2-vitamin D3, 25(OH)-vitamin D3, parathyroid hormone (PTH) in 82 male patients with primary gout whose serum uric acid was significantly higher than that of 41 normal control male subjects (8.8 ± 0.2 vs 5.6 ± 0.2 mg/dL, p < 0.001). The serum l,25(OH)2-vitamin D3 concentration was significantly lower in the patients with gout compared with the control subjects (39.6 ± 1.4 vs 44.8 ± 1.7 pg/mL, p < 0.05), while no differences were observed between the two groups in either the serum concentration of 25(OH)-vitamin D3 or PTH. The administration of uric acid lowering agent to the patients for 1 year caused a significant increase in their serum 1,25(OH)2- vitamin D3 concentration which was associated with a significant decrease in their serum uric acid concentration. In contrast, the serum concentrations of 25(OH)-vitamin D3 and PTH were not affected by these drugs. These results suggest that uric acid per se may directly decrease the serum concentration of l,25(OH)2-vitamin D3 in patients with gout by inhibiting 1 -hydroxylase activity.
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References
Vanholder R, Patel S, Hsu CH:Effect of uric acid on plasma levels of 1,25(OH)2D3 in renal failure. J Am Soc Nephrol 4: 1035–1038, 1993.
Lind L, Hanni A, Lithell H, Hvarfner A, Sorenson OH, Ljunghall S:Vitamin D is related to blood pressure and other cardiovascular risk factors in middle-aged men. Am J Hypertens 8: 894–901, 1995.
Scragg R, Holdaway I, Singh V, Metcalf P, Baker J, Dryson E:Serum 25-hydroxyvitamin D3 levels decreased in impaired glucose tolerance and diabetes mellitus. Diabetes Res Clin Pract 27: 181–188, 1995.
Stamp TCB, Round JM:Seasonal changes in human plasma levels of 25-hydroxyvitamin D. Nature 247: 563–565, 1974.
Kerstetter J, Caballero B, O’Brien K, Wurtrman R, Allen L:Mineral homeostasis in obesity:effect of euglycemic hyperinsulinemia. Metabolism 40: 707–713, 1991.
Liel Y, Ulmer E, Shary J, Hollis BW, Bell NH:Low circulating vitamin D in obesity. Calcif Tissue Int 43: 199–201, 1988.
Scragg R, Holdaway I, Jackson R, Lim T:Plasma 25-hydroxyvitamin D3 and its relation to physical activity and other heart disease risk factors in the general population. Ann Epidemiol 2: 697–703, 1992.
Kokot F, Pietrek J, Srokowska S, et al:25-hydroxyvitamin D in patients with essential hypertension. Clin Nephrol 16: 188–192, 1981.
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Takahashi, S., Yamamoto, T., Moriwaki, Y., Tsutsumi, Z., Yamakita, Ji., Higashino, K. (1998). Decreased Serum Concentrations of 1,25(OH)2-Vitamin D3 in Patients with Gout. In: Griesmacher, A., Müller, M.M., Chiba, P. (eds) Purine and Pyrimidine Metabolism in Man IX. Advances in Experimental Medicine and Biology, vol 431. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5381-6_11
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DOI: https://doi.org/10.1007/978-1-4615-5381-6_11
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