Abstract
Vagal stimulation inhibits brainstem neuronal discharge and induces slow wave sleep (SWS) and rapid eye movements (REM) sleep in the cat3,2,8. It also inhibits motor activity10. Low-voltage vagal stimulation also significantly reduces EEG spiking activity of a cortical epileptic focus caused by topical application of strychnine12 and prevents or aborts electrically and chemically induced seizures in rats13 as well as PTZ induced seizures in dogs14. In a previous work4 we described signs of paradoxical (REM) sleep that appear during the extinction of experimental seizures, suggesting a close relationship between the appearance of REM sleep and seizure arrest. The vagal stimulation as a novel approach for seizure control in patients who have intractable epilepsy has been recently documented7,6. In the present study we assessed the efficacy of vagal nerve stimulation on the development of electrographic and behavioral changes induced by kindling the amygdala (KA) as measured by the reduction in the frequency, duration and cortical propagation of amygdaloid afterdischarge.
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References
Calvo, J.M., Datta, S., Quattrochi, J. and Hobson, J. A., Cholinergic microstimulation of the Peribrachial nu-cleus in the cat. 11. Delayed and prolonged increases in REM sleep, Arch. Ital. Biol., 130 (1992) 285–301.
Chase, M.H., Nakamura, Y. and Clemente, C.D., Afferent vagal stimulation: neurographic correlates of induce EEG synchronization and desynchronization, Brain Res., 5 (1967) 236–249.
Dell, P. and Olson P., Projections secondaires mesencephaliques, encephaliques et amygdaliennes des afferences viscerales vagales, C. R. Soc. Biol. (Paris), 145 (1951) 1088–1091.
Fernández-Guardiola, A. and Ayala, F., Red nucleus fast activity and signs of paradoxical sleep appearing during the extinction of experimental seizures, Electroenceph. clin. Neurophysiol., 30 (1971) 547–555.
Fernández-Guardiola, A., Martinez, A. and Fernandez-Mas, R., Repeated penicillin-induced amygdala epileptic focus in freely moving cats. EEG, polysomnographic (23-h recording), and brain mapping study, Epilepsy Res., 22 (1995) 127–136.
Hammond, E. J., Uthman, B. M., Reid, S.A., Wilder, B.J. and Ramsay, R.E., Vagus nerve stimulation in humans: Neurophysiological studies and electrophysiological monitoring, Epilepsia (Suppl. 2), 31 (1990) 51–59.
Penry, J.K. and Dean, J.C., Prevention of intractable partial seizures by intermittent vagal stimulation in humans: Preliminary results, Epilepsia (Suppl. 2), 31 (1990) 40–43.
Puizillout, J. J., Vago-aortic nerves stimulation and REM sleep: evidence for a REM-triggering and a REM-maintenance factor, Brain Res., 196 (1976) 81–184.
Puizillout, J. J., Ternaux, J. P., Foutz, A.S. and Dell, P., Phases de sommeil à ondes lentes avec déscharges phasiques. Leur déclenchement par la stimulation vago-aortique, Rev. EEG Neurophysiol., 3 (1973) 21–37.
Schweitzer, A. and Wright, S., Effects on the knee jerk of stimulation of the central end of vagus nerve and of various changes in the circulation and respiration, J. Physiol. (Lond), 88 (1937) 459–475.
Snider, R.S. and Niemer, W.T., A Stereotaxic Atlas of the Cat Brain, University of Chicago Press, Chicago, II., 1961.
Stoica, I. and Tudor, I., Effects of vagus afferents on strychninic focus of coronal gyrus, Rev. Roum. Neural., 4 (1967) 287–295.
Woodbury, D. M. and Woodbury, J. W., Effects of vagal stimulation on experimentally induced seizures in rats, Epilepsia (suppl. 2), 31 (1990) 7–19.
Zabara, J., Inhibition of experimental seizures in canines by repetitive vagal stimulation, Epilepsia, 33 (1992) 1005–1012.
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Fernández-Guardiola, A., Martínez-Cervantes, A., Valdés-Cruz, A., Magdaleno-Madrigal, V., Fernández-Mas, R. (1998). Vagus Nerve Stimulation. In: Corcoran, M.E., Moshé, S.L. (eds) Kindling 5. Advances in Behavioral Biology, vol 48. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5375-5_35
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DOI: https://doi.org/10.1007/978-1-4615-5375-5_35
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