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The Syndrome of Mesial Temporal Lobe Epilepsy

A Role for Kindling

  • Chapter
Kindling 5

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 48))

Abstract

For almost three decades kindling has been a popular experimental tool for investigating enduring changes in neuronal excitability that presumably utilize natural mechanisms underlying normal as well as abnormal behaviors. The most common rationale for its use has been its presumed relevance to human epileptogenesis, and it has been referred to by many as “the kindling model of epilepsy.” Strictly speaking, however, routine kindling is not a model for epilepsy, because animals do not experience spontaneous seizures. Nevertheless, changes clearly occur that increasingly dispose specific brain regions to generate epileptic seizures, given an appropriate stimulus.

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Authors and Affiliations

  1. Departments of Neurology and Neurobiology and the Brain Research Institute, UCLA School of Medicine, Los Angeles, California, USA

    Jerome Engel Jr.

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  1. Jerome Engel Jr.
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  1. University of Saskatchewan, Saskatoon, Saskatchewan, Canada

    Michael E. Corcoran

  2. Albert Einstein College of Medicine, Bronx, New York, USA

    Solomon L. Moshé

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Engel, J. (1998). The Syndrome of Mesial Temporal Lobe Epilepsy. In: Corcoran, M.E., Moshé, S.L. (eds) Kindling 5. Advances in Behavioral Biology, vol 48. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5375-5_33

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  • DOI: https://doi.org/10.1007/978-1-4615-5375-5_33

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  • Print ISBN: 978-1-4613-7453-4

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