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Kindling: A Pathologic Activity-Driven Structural and Functional Plasticity in Mature Brain

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Book cover Kindling 5

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 48))

Abstract

Neuroscientists and clinicians are familiar with the idea that physiologic activity is required for stabilization of neuronal connections during development of the mammalian nervous system. Probably the best example is the requirement for physiologic activity in the normal development of the visual system. Hubel and Wiesel1 demonstrated that suturing an eyelid early in life dramatically modified ocular dominance column formation: neurons in the visual cortex that would normally have been driven by both eyes now were driven only by the eye that remained open. These and related findings led to recognition of the cause of diminished vision in children with strabismus and to treatments which encouraged use of both eyes.

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References

  1. Wiesel, T.N. and Hubel, D.H., Single cell responses in striate cortex of kittens deprived of vision in one eye, J. Neurophysiol., 26 (1963) 1003–1017.

    PubMed  CAS  Google Scholar 

  2. McNamara, J.O., Cellular and molecular basis of epilepsy, J. Neurosci., 14 (1994) 3413–3425.

    PubMed  CAS  Google Scholar 

  3. Sutula, T., He, X.X., Cavazos, J. and Scott, G., Synaptic reorganization in the hippocampus induced by abnormal functional activity, Science, 239 (1988) 1147–1150.

    Article  PubMed  CAS  Google Scholar 

  4. Nadler, J.V., Perry, B.W. and Cotman, C.W., Selective reinnervation of hippocampal area CA1 and the fascia dentata after destruction of CA3–CA4 afferents with kainic acid, Brain Res., 182 (1980) 1–9.

    Article  PubMed  CAS  Google Scholar 

  5. Tauck, D.L. and Nadler, J.V., Evidence of functional mossy fiber sprouting in hippocampal formation of kainic acid-treated rats, J. Neurosci.,5 (1985) 1016–1022.

    PubMed  CAS  Google Scholar 

  6. Wuarin, J.-P. and Dudek, F.E., Electrographic seizures and new recurrent excitatory circuits in the dentate gyrus of hippocampal slices from kainate-treated epileptic rats, J. Neurosci., 16 (1996) 4438–4448.

    PubMed  CAS  Google Scholar 

  7. Racine, R.J., Modification of seizure activity by electrical stimulation. II. Motor seizure, Electroenceph. clin. Neurophysiol., 32 (1972) 281–294.

    Article  PubMed  CAS  Google Scholar 

  8. Vosu, H. and Wise, R.A., Cholinergic seizure kindling in the rat: comparison of caudate, amygdala, and hippocampus, Behay. Biol., 13 (1975) 491–496.

    Article  CAS  Google Scholar 

  9. Wasterlain, C.G. and Jonec, V., Chemical kindling by muscarinic amygdaloid stimulation in the rat, Brain Res., 271 (1983) 311–316.

    Article  PubMed  CAS  Google Scholar 

  10. Somjen, G.G., Aitken, P.C., Giacchino, J.L. and McNamara, J.O., Sustained potential shifts and paroxysmal discharges in hippocampal formation, J. Neurophysiol., 53 (1985) 1079–1097.

    PubMed  CAS  Google Scholar 

  11. Schweitzer, J.S., Patrylo, P.R. and Dudek, F.E., Prolonged field bursts in the dentate gyrus: dependence on low calcium, high potassium, and nonsynaptic mechanisms, J. Neurophysiol., 68 (1992) 2016–2025.

    PubMed  CAS  Google Scholar 

  12. Stringer, J.L. and Lothman, E.W., Bilateral maximal dentate activation is critical for the appearance of an afterdischarge in the dentate gyrus, Neuroscience, 46 (1992) 309–314.

    Article  PubMed  CAS  Google Scholar 

  13. Traynelis, S.F. and Dingledine, R., Potassium-induced spontaneous electrographic seizures in the rat hippocampal slice, J. Neurophysiol., 59 (1988) 259–276.

    PubMed  CAS  Google Scholar 

  14. McNamara, J.O., Russell, R.D., Rigsbee, L. and Bonhaus, D.W., Anticonvulsant and antiepileptogenic actions of MK-801 in the kindling and electroshock models, Neuropharmacology, 27 (1988) 563–568.

    Article  PubMed  CAS  Google Scholar 

  15. McNamara, J.O., Bonhaus, D.W., Nadler, J.V. and Yeh, G.C., N-methyl-D-aspartate (NMDA) receptors and the kindling model, in Wada, J.A. (Ed.), Kindling 4, Plenum Press, New York, 1990, pp. 197–208.

    Chapter  Google Scholar 

  16. Callaghan, D.A. and Schwark, W.S., Pharmacological modification of amygdaloid-kindled seizures, Neuropharmacologw, 19 (1980) 1131–1136.

    Article  CAS  Google Scholar 

  17. Bowyer, J.F. and Winters, E.D., The effects of various anesthetics on amygdaloid kindled seizures, Neuro-pharmacology, 20 (1981) 199–204.

    CAS  Google Scholar 

  18. Bowyer, J.F., Phencyclidine inhibition of the rate of kindling development, Exp. Neurol., 75 (1982) 173–178.

    Article  PubMed  CAS  Google Scholar 

  19. Bowyer, J.F., Albertson, T.E., Winters, W.D. and Baselt, R.C., Ketamine-induced changes in kindled amygdaloid seizures, Neuropharmacology, 22 (1983) 887–892.

    Article  PubMed  CAS  Google Scholar 

  20. Holmes, K.H. and Goddard, G.V., A role for the N-methyl-D-aspartate receptor in kindling, Proc. Univ. Otago Med. Sch., 64 (1986) 37–42.

    Google Scholar 

  21. Holmes, K.H., Bilkey, D.K., Laverty, R. and Goddard, G.V., The N-methyl-D-aspartate antagonists aminophosphonovalerate and carboxypiperazinephosphonate retard the development and expression of kindled seizures, Brain Res., 506 (1990) 227–235.

    Article  PubMed  CAS  Google Scholar 

  22. Cain, D.P., Desborough, K.A. and McKitrick, D.J., Retardation of amygdaloid kindling by antagonism of NMD-aspartate and muscarinic cholinergic receptors: evidence for the summation of excitatory mechanisms in kindling, Exp. Neurol., 100 (1988) 203–208.

    Article  PubMed  CAS  Google Scholar 

  23. Vezzani, A., Wu, H.Q., Moneta, E. and Samanin, R., Role of the N-methyl-D-aspartate-type receptors in the development and maintenance of hippocampal kindling in rats, Neurosci. Lett., 87 (1988) 63–68.

    Article  PubMed  CAS  Google Scholar 

  24. Croucher, M.J., Cotterell, K.L., and Bradford, H.F., Amygdaloid kindling by repeated focal N-methyl-Daspartate administration: comparison with electrical kindling, Eur: J. Pharmacol., 286 (1995) 265–271.

    Article  CAS  Google Scholar 

  25. Durmuller, N., Craggs, M. and Meldrum, B.S., The effect of the non-NMDA receptor antagonists GYKI 52466 and NBQX and the competitive NMDA receptor antagonist D-CPPene on the development of amygdala kindling and on amygdala-kindled seizures, Epilepsy Res., 17 (1994) 167–174.

    Article  PubMed  CAS  Google Scholar 

  26. Kaura, S., Bradford, H.F., Young, A.M.J., Croucher, M.J. and Hughes, P.D., Effect of amygaloid kindling on the content and release of amino acids from the amygdaloid complex: in vivo and in vitro studies, J. Neurochem. 65 (1995) 1240–1249.

    Article  PubMed  CAS  Google Scholar 

  27. Morgan, J.I. and Curran, T., Role of ion flux in the control of c-fos expression, Nature, 322 (1986) 552–555.

    Article  PubMed  CAS  Google Scholar 

  28. Goelet, R, Castellucci, V.F., Schacher, S. and Kandel, E.R., The long and short of long-term memory-a molecular framework, Nature, 322 (1986) 419–422.

    Article  PubMed  CAS  Google Scholar 

  29. Morgan, J.I., Cohen, D.R., Hempstead, J.L. and Curran, T., Mapping patterns of c-fos expression in the central nervous system after seizure, Science, 237 (1987) 192–197.

    Article  PubMed  CAS  Google Scholar 

  30. Dragunow, M. and Robertson, H.A., Kindling stimulation induces c-fos protein(s) in granule cells of the rat dentate gyrus, Nature, 329 (1987) 441–442.

    Article  PubMed  CAS  Google Scholar 

  31. Simonato, M., Hosford, D.A., Labiner, D.M., Shin, C., Mansbach, H.H. and McNamara, J.O., Differential expression of immediate early genes in the hippocampus in the kindling model of epilepsy, Mol. Brain Res., 11 (1991) 115–124.

    Article  PubMed  CAS  Google Scholar 

  32. Hosford, D.A., Simonato, M., Cao, Z., Garcia-Cairasco, N., Silver, J.M., Butler, L., Shin, C. and McNamara, J.O., Differences in the anatomic distribution of immediate-early gene expression in amygdala and angular bundle kindling, J. Neurosci., 15 (1995) 2513–2523.

    PubMed  CAS  Google Scholar 

  33. Clark, M., Post, R.M., Weiss, S.R.B., Cain, C.J. and Nakajima, T., Regional expression of c-fos mRNA in rat brain during the evolution of amygdala kindled seizures, Mol. Brain Res., 11 (1991) 55–64.

    Article  PubMed  CAS  Google Scholar 

  34. Bonhaus, D.W., Walters, J.R. and McNamara, J.O., Activation of substantia nigra neurons: role in the propagation of seizures in kindled rats, J. Neurosci., 6 (1986) 3024–3030.

    PubMed  CAS  Google Scholar 

  35. Bonhaus, D.W., Russell, R.D. and McNamara, J.O., Activation of substantia nigra pars reticulata neurons: role in the initiation and behavioral expression of kindled seizures, Brain Res., 545 (1991) 41–48.

    Article  PubMed  CAS  Google Scholar 

  36. Labiner, D.M., Butler, L.S., Cao, Z., Hosford, D.A., Shin, C. and McNamara, J.O., Induction of c-fos mRNA by kindled seizures: complex relationship with neuronal burst firing, J. Neurosci., 13 (1993) 744–751.

    PubMed  CAS  Google Scholar 

  37. Johnson, R.S., Spiegelman, B.M. and Papaioannou, V., Pleiotropic effects of a null mutation in the c-fos proto-oncogene, Cell, 71 (1992) 577–586.

    Article  PubMed  CAS  Google Scholar 

  38. Watanabe, Y., Johnson, R.S., Butler, L.S., Binder, D.K., Spiegelman, B.M., Papaioannou, V.E. and McNamara, J.O., Null mutation of c-fos impairs structural and functional plasticities in the kindling model of epilepsy, J. Neurosci., 16 (1996) 3827–3836.

    PubMed  CAS  Google Scholar 

  39. Gall, C.M. and Isackson, P.J., Limbic seizures increase neuronal production of messenger RNA for nerve growth factor, Science, 245 (1989) 758–761.

    Article  PubMed  CAS  Google Scholar 

  40. Ernfors, P., Bengzon, J., Kokaia, Z., Persson, H. and Lindvall, O., Increased levels of messenger RNAs for neurotrophic factors in the brain during kindling epileptogenesis, Neuron, 7 (1991) 165–176.

    Article  PubMed  CAS  Google Scholar 

  41. Gall, C.M., Seizure-induced changes in neurotrophin expression: implications for epilepsy, Exp. Neural., 124 (1993) 150–166.

    Article  CAS  Google Scholar 

  42. Bengzon, J., Kokaia, Z., Ernfors, P., Kokaia, M., Leanza, G., Nilsson, O.G., Persson, H. and Lindvall, O., Regulation of neurotrophin and trkA and trkC tyrosine kinase receptor messenger RNA expression in kindling, Neuroscience, 53 (1993) 433–436.

    Article  PubMed  CAS  Google Scholar 

  43. Bugra, K., Pollard, H., Charton, G., Moreau, J., Ben-Ari, Y., Khrestchatisky, M., aFGF, bFGF and flg mRNAs show distinct patterns of induction in the hippocampus following kainate-induced seizures, Eue. J. Neurosci., 6 (1994) 58–66.

    Article  CAS  Google Scholar 

  44. Gall, C.M., Berschauer, R. and Isackson, P.J., Seizures increase basic fibroblast growth factor mRNA in adult rat forebrain neurons and glia, Mol. Brain Res., 21 (1994) 190–205.

    Article  PubMed  CAS  Google Scholar 

  45. Bendotti, C., Vezzani, A., Tarizzo, G. and Samanin, R., Increased expression of GAP-43, somatostatin and neuropeptide Y mRNA in the hippocampus during development of hippocampal kindling in rats, Eur. J. Neurosci., 5 (1993) 1312–1320.

    Article  PubMed  CAS  Google Scholar 

  46. Meberg, P.J., Gall, C.M. and Routtenberg, A., Induction of F1/GAP-43 gene: expression in hippocampal granule cells after seizures, Mol. Brain Res., 17 (1993) 295–297.

    Article  PubMed  CAS  Google Scholar 

  47. Patel, M.N., and McNamara, J.O., Selective enhancement of axonal branching of cultured dentate gyrus neurons by neurotrophic factors, Neuroscience, 69 (1995) 763–770.

    Article  PubMed  CAS  Google Scholar 

  48. Lowenstein, D.H. and Arsenault, L., The effects of growth factors on the survival and differentiation of cultured dentate gyrus neurons, J. Neurosci., 16 (1996) 1759–1769.

    PubMed  CAS  Google Scholar 

  49. Funabashi, T., Sasaki, H. and Kimura, F., Intraventricular injection of antiserum to nerve growth factor delays the development of amygdaloid kindling, Brain Res., 458 (1988) 132–136.

    Article  PubMed  CAS  Google Scholar 

  50. Van der Zee, C.E.E.M., Rashid, K., Le, K., Moore, K.A., Stanisz, J., Diamond, J., Racine, R.J. and Fahnestock, M., Intraventricular administration of antibodies to nerve growth factor retards kindling and blocks mossy fiber sprouting in adult rats, J. Neurosci., 15 (1995) 5316–5323.

    PubMed  Google Scholar 

  51. Kokaia, M., Ernfors, P., Kokaia, Z., Elmer, E., Jaenisch, R. and Lindvall, O., Suppressed epileptogenesis in BDNF mutant mice, Exp. Neural., 133 (1995) 215–224.

    Article  CAS  Google Scholar 

  52. Aigner, L., Arber, S., Kapfliammer, J.P., Laux, T., Schneider, C., Botteri, F., Brenner, H.-R. and Caroni, R, Overexpression of the neural growth-associated protein GAP-43 induces nerve sprouting in the adult nervous system of transgenic mice, Cell, 83 (1995) 269–278.

    Article  PubMed  CAS  Google Scholar 

  53. Shibata, F., Baird, A. and Florkiewicz, R.Z., Functional characterization of the human basic fibroblast growth factor gene promoter, Growth Factors, 4 (1991) 277–287.

    Article  PubMed  CAS  Google Scholar 

  54. Nedivi, E., Basi, G.S., Akey, I.V. and Skene, J.H., A neural-specific GAP-43 core promoter located between unusual DNA elements that interact to regulate its activity, J. Neurosci., 12 (1992) 691–704.

    PubMed  CAS  Google Scholar 

  55. Pennypacker, K.R., Hong, J.-S. and McMillian, M.K., Implications of prolonged expression of Fos-related antigens, Trends Pharmacol. Sci., 16 (1995) 317–321.

    Article  PubMed  CAS  Google Scholar 

  56. Cavazos, J.E. and Sutula, T.P., Progressive neuronal loss induced by kindling: a possible mechanism for mossy fiber synaptic reorganization and hippocampal sclerosis, Brain Res., 527 (1990) 1–6.

    Article  PubMed  CAS  Google Scholar 

  57. Cavazos, J.E., Das, I. and Sutula, T.P., Neuronal loss induced in limbic pathways by kindling: evidence for induction of hippocampal sclerosis by repeated brief seizures, J. Neurosci., 14 (1994) 3106–3121.

    PubMed  CAS  Google Scholar 

  58. Bertram, E.H., Lothman, E.W. and Lenn, N.J., The hippocampus in experimental chronic epilepsy: a morphometric analysis, Ann. Neurol., 27 (1990) 43–48.

    Article  PubMed  CAS  Google Scholar 

  59. Bertram, E.H. and Lothman, E.W., Morphometric effects of intermittent kindled seizures and limbic status epilepticus in the dentate gyrus of the rat, Brain Res., 603 (1993) 25–31.

    Article  PubMed  Google Scholar 

  60. Purves, D., Neural activity and the growth of the brain, Cambridge University Press, Cambridge, UK, 1994.

    Google Scholar 

  61. Trujillo, K.A. and Akil, H., Inhibition of morphine tolerance and dependence by the NMDA receptor antagonist MK-801, Science, 251 (1991) 85–87.

    Article  PubMed  CAS  Google Scholar 

  62. Ohmori, T., Abekawa, T., Muraki, A. and Koyama, T., Competitive and noncompetitive NMDA antagonists block sensitization to methamphetamine, Pharmacol. Biochem. Behay., 48 (1994) 587–591.

    Article  CAS  Google Scholar 

  63. Nestler, E.J., Hope, B.T., and Widnell, K.L., Drug addiction: a model for the molecular basis of neural plasticity, Neuron, 11 (1993) 995–1006.

    Article  PubMed  CAS  Google Scholar 

  64. Woolf, C.J. and Thompson, S.W.N., The induction and maintenance of central sensitization is dependent on N-methyl-D-aspartic acid receptor activation: implications for the treatment of post-injury pain hypersensitivity states, Pain, 44 (1991) 293–299.

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Neurobiology Epilepsy Research Laboratory, 401 Bryan Research Building, Duke University Medical Center, Durham, North Carolina, 27710, USA

    Devin K. Binder & James O. McNamara

  2. Department of Pharmacology Epilepsy Research Laboratory, 401 Bryan Research Building, Duke University Medical Center, Durham, North Carolina, 27710, USA

    James O. McNamara

  3. Department of Medicine (Neurology) Epilepsy Research Laboratory, 401 Bryan Research Building, Duke University Medical Center Durham, North Carolina, 27710, USA

    James O. McNamara

Authors
  1. Devin K. Binder
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  2. James O. McNamara
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Editor information

Editors and Affiliations

  1. University of Saskatchewan, Saskatoon, Saskatchewan, Canada

    Michael E. Corcoran

  2. Albert Einstein College of Medicine, Bronx, New York, USA

    Solomon L. Moshé

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Binder, D.K., McNamara, J.O. (1998). Kindling: A Pathologic Activity-Driven Structural and Functional Plasticity in Mature Brain. In: Corcoran, M.E., Moshé, S.L. (eds) Kindling 5. Advances in Behavioral Biology, vol 48. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5375-5_18

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  • DOI: https://doi.org/10.1007/978-1-4615-5375-5_18

  • Publisher Name: Springer, Boston, MA

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  • Online ISBN: 978-1-4615-5375-5

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