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Kindling 5 pp 179–191Cite as

Comparison of Synapse Remodeling Following Hippocampal Kindling and Long-Term Potentiation

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Part of the book series: Advances in Behavioral Biology ((ABBI,volume 48))

Abstract

Hippocampal kindling and long-term potentiation (LTP) are widely regarded as models of synaptic plasticity2,28,31. In the kindling paradigm23,24,a behaviorally ineffective electrical stimulus of a high frequency is delivered daily to a local forebrain area. This leads to progressive intensification of paroxysmal neuronal activity and alterations in motor behavior that culminate eventually in a generalized seizure. Once this response to the constant stimulus has been attained, cessation of stimulation for many months and even years does not result in the loss of the newly acquired abnormal reaction: reintroduction of the original stimulus reliably evokes a generalized seizure24,25,30,31,33,42.Thus, kindling involves a virtually permanent augmentation of synaptic responsiveness in the stimulated circuit.

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Author information

Authors and Affiliations

  1. Department of Cell and Molecular Biology, Northwestern University Medical School, Chicago, Illinois, 60611, USA

    Yuri Geinisman, Inna S. Persina & Eddy A. Van der Zee

  2. Department of Neurological Sciences, Rush Medical College, Chicago, Illinois, 60612, USA

    Frank Morrell & Leyla deToledo-Morrell

Authors
  1. Yuri Geinisman
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  2. Frank Morrell
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  3. Leyla deToledo-Morrell
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  4. Inna S. Persina
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  5. Eddy A. Van der Zee
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Editor information

Editors and Affiliations

  1. University of Saskatchewan, Saskatoon, Saskatchewan, Canada

    Michael E. Corcoran

  2. Albert Einstein College of Medicine, Bronx, New York, USA

    Solomon L. Moshé

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© 1998 Springer Science+Business Media New York

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Geinisman, Y., Morrell, F., deToledo-Morrell, L., Persina, I.S., Van der Zee, E.A. (1998). Comparison of Synapse Remodeling Following Hippocampal Kindling and Long-Term Potentiation. In: Corcoran, M.E., Moshé, S.L. (eds) Kindling 5. Advances in Behavioral Biology, vol 48. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5375-5_14

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  • DOI: https://doi.org/10.1007/978-1-4615-5375-5_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7453-4

  • Online ISBN: 978-1-4615-5375-5

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