Abstract
Complex partial seizures with secondary generalization are an enduring problem for many patients with temporal lobe epilepsy. The often intractible nature of these seizures can bring the patient to the surgeon for therapeutic relief. The problem for the surgeon, in this circumstance, is to identify the exact tissue that needs to be excised to provide that relief. Thus, a thorough understanding of the neurological substrates critical to the propagation of temporal lobe seizures is necessary in that assessment. There are several experimental animal models that could be applied to this problem, each with its own virtues and drawbacks. When applied to temporal lobe epilepsy, the kindling technique nicely models complex partial seizures with secondary generalization, and would appear to be a good model to assess the functional anatomy underlying the syndrome.
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References
Burchfiel, J.L. and Applegate, C.D., Forebrain and brainstem mechanisms governing seizure development: A hypothesis. In J.A. Wada (ed.), Kindling 4. Plenum Press, New York, 1990, pp. 93–112.
Burwell, R.D., Witter, M.P. and Amaral, D.G. Perirhinal and postrhinal cortices of the rat: A review of the neuroanatomical literature and comparison with findings from the monkey, Hippocampus, 5 (1995) 390–408.
Corcoran, M.E., Urstad, H., McCaughran, J.A., Jr. and Wada, J.A., Frontal lobe and kindling in the rat. In J.A. Wada (ed.), Kindling. Raven Press, New York, 1976, pp. 215–228.
Deacon, T.W., Eichenbaum, H., Rosenberg, P. and Eckmann, K.W., Afferent connections of the perirhinal cortex in the rat. J. Comp. Neurol., 220 (1983) 168–190.
Goddard, G.V., McIntyre, D.C. and Leech, C.K., A permanent change in brain function resulting from electrical stimulation, Exp. Neurol., 25 (1969) 295–330.
Haberly, L.B. and Bower, J.M., Analysis of association fiber system in piriform cortex with intracellular recording and staining techniques, J. Neurophysiol., 51 (1984) 90–112.
Haberly, L.B. and Sutula, T.P., Neuronal processes that underlie expression of kindled epileptiform events in the piriform cortex in vivo, J. Neurosci., 12 (1992) 2211–2224.
Holmes, K.H., Bilkey, D.K. and Laverty, R., The infusion of an NMDA antagonist in perirhinal cortex suppresses amygdala-kindled seizures, Brain Res., 587 (1992) 285–290.
Honack, D., Wahnschaffe, U. and Loscher, W., Kindling from stimulation of a highly sensitive locus in the posterior part of the piriform cortex: comparison with amygdala kindling and effects of antiepileptic drugs, Brain Res., 538 (1991) 196–202.
Kairiss, E.W., Racine, R.J. and Smith, G.K., The development of interictal spike during kindling in the rat, Brain Res., 322 (1984) 101–110.
Kelly, M.E. and McIntyre, D.C., Perirhinal cortex involvement in limbic kindled seizures, Epilepsy Res. (in press).
Kosel, K.C., Van Hoesen, G.W. and Rosene D.L., A direction projection from the perirhinal cortex (area 35) to the subiculum in the rat, Brain Res., 269 (1983) 347–351.
Kudo, T., and Wada, J.A., Claustrum and amygdaloid kindling. In J.A. Wada, (ed.), Kindling 4. Plenum Press, New York, 1990, pp. 397–408.
McIntyre, D.C. Split-brain rat: transfer and interference of amygdala kindled convulsions, Can. J. Neural. Sci., 2 (1975) 429–437.
McIntyre, D.C., Nathanson, D. and Edson, N., A new model of partial status epilepticus based on kindling, Brain Res., 250 (1982) 53–64.
McIntyre, D.C. and Wong, R.K.S., Modification of local neuronal interactions by amygdala kindling in vitro, Exp. Neurol., 88 (1985) 529–537.
McIntyre, D.C. and Wong, R.K.S., Cellular and synaptic properties of amygdala-kindled pyriform cortex in vitro, J. Neurophysiol., 55 (1986) 1295–1307.
McIntyre, D.C. (1986) Kindling and the pyriform cortex. In J.A. Wada (ed.), Kindling 3, Raven Press, New York, 1986, pp.249–262.
McIntyre, D.C. and Racine, R.J., Kindling mechanisms: current progress on an experimental epilepsy model, Prog. Neurobiol., 27 (1986) 1–12.
McIntyre, D.C. and Plant, J.R., Pyriform cortex involvement in kindling, Neurosci. Biobehay. Rev., 13 (1989) 277–280.
McIntyre, D.C. and Kelly, M.E., Is the pyriform cortex important for limbic kindling? In J.A. Wada (ed.), Kindling 4, Plenum Press, New York, 1990, pp. 21–31.
McIntyre, D.C., Kelly, M.E. and Armstrong, J.N., Kindling in the perirhinal cortex. Brain Res., 615 (1993) 1–6.
McIntyre, D.C., Kelly, M.E. and Staines, W.A., Efferent projections of the anterior perirhinal cortex in the rat, J. Comp. Neurol., 369 (1996) 302–318.
Paxinos, G. and Watson, C., The Rat Brain in Stereotaxic Coordinates, Academic Press, New York.
Piredda, S. and Gale, K., A crucial epileptogenic site in the deep prepiriform cortex. Nature, 317 (1985) 623–625.
Walther, H., Lambert, J.D.C., Jones, R.S.G., Heinemann, U and Hamon, B., Epileptiform activity in combined slices of the hippocampus, subiculum and entorhinal cortex during perfusion with low magnesium medium, Neurosci. Lett., 69 (1986) 156–161.
Witter, M.P. and Groenewegen, H.J., Connections of the parahippocampal cortex in the cat. III. Cortical and thalamic efferents. J. Comp. Neurol., 252 (1986) l-31.
Witter, M.P., Groenewegen, H.J., Lopes da Silva, F.H. and Lohman, A.H.M., Functional organization of the extrinsic and intrinsic circuitry of the parahippocampal region. Prog. Neurobiol., 33 (1989) 161–254.
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McIntyre, D.C., Kelly, M.E. (1998). The Perirhinal Cortex and Kindled Motor Seizures. In: Corcoran, M.E., Moshé, S.L. (eds) Kindling 5. Advances in Behavioral Biology, vol 48. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5375-5_13
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