Abstract
The stereotyped development of kindled seizures from all limbic system structures strongly suggests the recruitment of a common neuronal network for seizure expression. Our own research (see Burchfiel, Applegate, Samoriski and Nierenberg, this volume), as well as that of others, has implicated the involvement of several paleocortical regions including the ipsilateral piriform, ventral perirhinal and insular cortices in the transition from stage 2 to stage 3 kindled seizures, independent of the site of focal afterdischarge initiation.5,17,19,22,28 Thus, the evolution of afterdischarge driven species typical behaviors such as arrest, grooming and wet dog shakes (stages 1–2) to pronounced facial clonus and headnodding (stage 3) involves the recruitment of the ipsilateral piriform and insular cortices for behavioral seizure expression.
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Applegate, C.D., Burchfiel, J.L., Ferland, R.J., Nierenberg, J. (1998). The Role of Rhinencephalic Networks in the Late Stages of Kindling. In: Corcoran, M.E., Moshé, S.L. (eds) Kindling 5. Advances in Behavioral Biology, vol 48. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5375-5_12
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DOI: https://doi.org/10.1007/978-1-4615-5375-5_12
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