Abstract
During an infection of erythrocytes by the human malarial parasite Plasmodium falciparum, up to 80% of host cell haemoglobin is degraded to provide amino acids for parasite nutrition.1,2 Two aspartic proteinases, plasmepsin I and plasmepsin II are believed to be responsible for initiating this catabolic process3 and thus are suitable targets for antimalarial chemotherapy. These enzymes have 73% identity to each other and approximately 30%) identity to the five known human aspartic proteinases.
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Tyas, L. et al. (1998). Plasmepsins I and II from the Malarial Parasite Plasmodium falciparum . In: James, M.N.G. (eds) Aspartic Proteinases. Advances in Experimental Medicine and Biology, vol 436. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5373-1_57
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DOI: https://doi.org/10.1007/978-1-4615-5373-1_57
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