Abstract
Cleavage of non-viral proteins is rarely observed with the HIV-1 protease (HIV pr). One such cleavage event occurs with bcl-2, an important cytoprotective protein. The loss of bcl-2 has biological consequences, leading to enhanced HIV replication and programmed death of the host cell. A strategy is proposed to suppress HIV with non-cleavable mutants of bcl-2.
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© 1998 Springer Science+Business Media New York
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Korant, B.D., Strack, P., Frey, M.W., Rizzo, C.J. (1998). A Cellular Anti-Apoptosis Protein is Cleaved by the HIV-1 Protease. In: James, M.N.G. (eds) Aspartic Proteinases. Advances in Experimental Medicine and Biology, vol 436. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5373-1_3
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DOI: https://doi.org/10.1007/978-1-4615-5373-1_3
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