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31–27 kDa Caseinolytic Protease in Human Tears

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Lacrimal Gland, Tear Film, and Dry Eye Syndromes 2

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 438))

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Abstract

Normal wound healing requires the presence and regulation of cell adhesion proteins, proteases, and growth and other factors. Several of the proteases involved in tissue remodeling and wound healing have been detected in tear fluid. Previous studies on ocular pathologies have focused on the plasminogen-plasmin system1,2 and its role in fibrinolysis, which results in a decrease of epithelial cell adhesion and subsequent destruction of the basement membrane.3 This study was designed to identify other proteases reported in tear fluid that may impact ocular pathologies and wound healing.

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References

  1. Tervo T, Salonen EM, Vaheri A, et al. Elevation of tear fluid plasmin in corneal disease. Acta Ophthalmol. 1988; 66: 393–399.

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  2. Van Setten GB, Salonen EM, Vaheri A, et al. Plasmin and plasminogen activator activities in tear fluid during corneal wound healing after anterior keratectomy. Curr Eye Res. 1989; 8: 1293–1298.

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  3. Liotta LA, Goldfarb RH, Brundage R, Siegel GP, Terranova V, Garbisa S. Effect of plasmin activator (urokinase), plasmin and thrombin on glycoprotein and collagenous components of basement membrane. Cancer Res. 1981; 41: 4629–4636.

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  4. Hamdi HK, Berjis F, Brown DJ, Kenney MC. Protease activity in normal human tears: Male-female dimorphism. Curr Eye Res. 1995; 14: 1081–1086.

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Biological Sciences, State University of New York State College of Optometry, New York, New York, USA

    Miki Sakata, Ann R. Beaton, Sonal Sathe & Robert A. Sack

  2. CRCERT, University of New South Wales, Sydney, Australia

    Robert A. Sack

Authors
  1. Miki Sakata
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  2. Ann R. Beaton
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  3. Sonal Sathe
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  4. Robert A. Sack
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Editor information

Editors and Affiliations

  1. The Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts, USA

    David A. Sullivan  & Darlene A. Dartt  & 

  2. Louisiana State University Medical Center, New Orleans, Louisiana, USA

    Michele A. Meneray

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© 1998 Springer Science+Business Media New York

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Sakata, M., Beaton, A.R., Sathe, S., Sack, R.A. (1998). 31–27 kDa Caseinolytic Protease in Human Tears. In: Sullivan, D.A., Dartt, D.A., Meneray, M.A. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes 2. Advances in Experimental Medicine and Biology, vol 438. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5359-5_94

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  • DOI: https://doi.org/10.1007/978-1-4615-5359-5_94

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7445-9

  • Online ISBN: 978-1-4615-5359-5

  • eBook Packages: Springer Book Archive

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