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Rat Lacrimal Glands Contain Activated and Resting Mature T Cells, Recent Thymic Emigrants, and Possibly Extrathymic Populations

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Lacrimal Gland, Tear Film, and Dry Eye Syndromes 2

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 438))

Abstract

Lacrimal glands (LG) possess both transient and stationary lymphocyte populations, distinct from those in peripheral lymphoid sites, which regulate and effect humoral and cell-mediated immune responses contributing to the protection of ocular surfaces.1,2 Further, lacrimal glands are sites of lymphocytic infiltration in inflammatory disorders such as Sjögren’s syndrome. Earlier work has established that rat lacrimal gland lymphocytes display a distinct phenotypic profile compared to nonmucosal lymphoid tissues.3,4 Of particular interest is the presence of lymphocytes expressing Thy-1, which, in the rat, is found on immature B and T lymphocytes in bone marrow and thymus5,6 as well as on their recently released progeny in the periphery. The Thy-1 molecule is lost with increasing maturity.7,8 In the case of T cells, developmental stages, including immature recent thymic emigrants (RTE), mature common peripheral T cells (CPT), and activated T cells that have recently encountered antigen, can be identified on the basis of size and expression of Thy-1 and CD45RC.7,8

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Authors and Affiliations

  1. Department of Immunology and Microbiology, Wayne State University Medical School, Detroit, Michigan, USA

    Nancy L. O’Sullivan, Cheryl A. Skandera & Paul C. Montgomery

Authors
  1. Nancy L. O’Sullivan
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  2. Cheryl A. Skandera
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  3. Paul C. Montgomery
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Editor information

Editors and Affiliations

  1. The Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts, USA

    David A. Sullivan  & Darlene A. Dartt  & 

  2. Louisiana State University Medical Center, New Orleans, Louisiana, USA

    Michele A. Meneray

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O’Sullivan, N.L., Skandera, C.A., Montgomery, P.C. (1998). Rat Lacrimal Glands Contain Activated and Resting Mature T Cells, Recent Thymic Emigrants, and Possibly Extrathymic Populations. In: Sullivan, D.A., Dartt, D.A., Meneray, M.A. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes 2. Advances in Experimental Medicine and Biology, vol 438. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5359-5_83

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  • DOI: https://doi.org/10.1007/978-1-4615-5359-5_83

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7445-9

  • Online ISBN: 978-1-4615-5359-5

  • eBook Packages: Springer Book Archive

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