Abstract
Dry eye is the ocular manifestation of a collective secretory deficiency by lacrimal acinar cells.1 Lacrimal acinar cells are polarized tear protein factories, with tear protein-filled secretory granules packed in the apical cytoplasm adjacent to the acinar lumen into which tear proteins are released. These cells are wrapped into acini by a poorly characterized basement membrane2 sheet, the complex cellular adhesiveness of which is the molecular basis for exocrine cell polarity.3 Abnormality of the basement membrane-cell interface is the primary lesion in several autoimmune and genetic diseases.4 In Goodpasture’s syndrome, for example, nephrotoxic autoantibodies appear as a consequence of infection-associated exposure of a sequestered epitope in the α3 chain of collagen IV. In Alport’s syndrome, function-altering point mutations in the collagen IV α3 chain have been detected.
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Sullivan DA, Wickham A, Krenzer KL, Rocha EM, Toda I. Aqueous tear deficiency in Sjögren’s syndrome. In: Pleyer U, Hartmann C, Sterry W, eds. Oculodermal Diseases–Immunology of Bullous OculoMuco-Cutaneous Disorders. Berlin: Aeolus Press; 1997. pp. 95–152.
Timpl R. Structure and biological activity of basement membrane proteins. Eur J Biochem. 1989; 120: 487–502.
Nelson WJ, Wang AZ, Ojakian GK. Steps in the morphogenesis of a polarized epithelium. J Cell Sci. 1990; 95: 153–165.
Hudson BG, Reeders ST, Tryggvason K. Type IV collagen: Structure, gene organization, and role in human diseases. Molecular basis of Goodpasture and Alport syndromes and diffuse leiomyomatosis. J Biol Chem. 1993; 268: 26033–26036.
Payrastre B, vanBergen en Henegouwen PM, Brenton M, et al. Phosphoinositide kinase, diacylglycerol kinase, and phospholipase C activities associated to the cytoskeleton: Effect of epidermal growth factor. J Cell Biol. 1991; 115: 121–128.
Jamieson JD. Plasmalemmal glycoproteins and basal lamina: Involvement in pancreatic morphogenesis. Prog Clin Biol Res. 1982; 91: 413–427.
Laurie GW, Glass JD, Ogle RA, Stone CM, Sluss JR, Chen L. BMI80: A novel basement membrane protein with a role in stimulus-secretion coupling by lacrimal acinar cells. Am J Physiol. 1996; 270: C1743 - C1750.
Laurie GW, Ciclitira Pi, Ellis HJ, Pogany G. Immunological and partial sequence identity of mouse BM180 with wheat a-gliadin. Biochem Biophys Res Commun. 1995; 217: 10–15.
Teppo A-M, Maury CPJ. Antibodies to gliadin, gluten and reticulin glycoprotein in rheumatic diseases: Elevated levels in Sjögren’s syndrome. Clin Exp Immunol. 1984; 57: 73–78.
Hann LE, Kelleher RS, Sullivan DA. Influence of culture conditions on the androgen control of secretory component production by acinar cells from the rat lacrimal gland. Invest Ophthalmol Vis Sci. 1991; 32: 2610–2621.
Matter ML, Laurie GW. A novel laminin E8 cell adhesion site required for lung alveolar formation in vitro. J Cell Biol. 1994; 124: 1083–1090.
Bromberg BB, Cripps MM, Welch MH. Peroxidase secretion by lacrimal glands from juvenile F344 rats. Invest Ophthalmol Vis Sci. 1989; 30: 562–568.
Dam DA, Baker AK, Rose PE, Murphy SA, Ronco LV, Unser ME. Role of cyclic AMP and Ca2+ in potentiation of rat lacrimal gland protein secretion. Invest Ophthalmol Vis Sci. 1988; 29: 1732–1738.
Ley K, Bullard DC, Arbones ML, et al. Sequential contribution of P-selectin to leukocyte rolling in vivo. J Exp Med. 1995; 181: 669–675.
Fox RI, Luppi M, Kang HI, Pisa P. Reactivation of Epstein-Barr virus in Sjögren’s syndrome. Springer Semin Immunopathol.. 1991; 13: 217–231.
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Asrani, A.C., Lumsden, A.J., Kumar, R., Laurie, G.W. (1998). Gene Cloning of BM180, a Lacrimal Gland Enriched Basement Membrane Protein with a Role in Stimulated Secretion. In: Sullivan, D.A., Dartt, D.A., Meneray, M.A. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes 2. Advances in Experimental Medicine and Biology, vol 438. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5359-5_4
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DOI: https://doi.org/10.1007/978-1-4615-5359-5_4
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