Skip to main content

Cellular Origin of Mucins of the Ocular Surface Tear Film

  • Chapter
Lacrimal Gland, Tear Film, and Dry Eye Syndromes 2

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 438))

Abstract

The surface of the eye is covered by a tear film that has been estimated to be 40 μm thick.1.2 The film is extraordinarily regular over the cornea where it is the primary refractive surface of the eye. The mucus within the tear film provides the major structural component of the layer, and recent estimates of its thickness, 30 μm, suggest that it contributes most of the thickness of the tear film. The mucus layer has been estimated to be thicker and more viscous at the very apical surface of the epithelial cells, with a diminution of viscosity towards the tear film surface.3

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Prydal JI, Campbell FW. Study of precorneal tear film thickness and structure by interferometry and confocal microscopy. Invest Ophthalmol Vis Sei. 1992; 33: 1996–2005.

    CAS  Google Scholar 

  2. Prydal JI, Artal P, Woon H, Campbell FW. Study of human precorneal tear film thickness and structure using laser interferometry. Invest Ophthalmol Vis Sci. 1992; 33: 2006–2011.

    CAS  PubMed  Google Scholar 

  3. Dilly PN. Structure and function of the tear film. Adv Exp Med Biol. 1994; 350: 239–247.

    Article  CAS  PubMed  Google Scholar 

  4. Carlstedt I, Sheehan JK, Corfield AP, Gallagher JT. Mucous glycoproteins: A gel of a problem. Essays Biochem. 1985; 20: 40–76.

    CAS  PubMed  Google Scholar 

  5. Strous GJ, Dekker J. Mucin-type glycoproteins. Crit Rev Biochem Mol Biol. 1992; 27: 57–92.

    Article  CAS  PubMed  Google Scholar 

  6. Gendler Si, Spicer AP. Epithelial mucin genes. Annu Rev Physiol. 1995; 57: 607–634.

    Article  CAS  PubMed  Google Scholar 

  7. Keates AC, Nunes DP, Afdhal NH, Troxler RF, Offner GD. Molecular cloning of a major human gallbladder mucin. Complete carboxyl-terminal sequence and genomic organization of the D4 domain of MUC5B. Biochem J. in press.

    Google Scholar 

  8. Sadler JE. von Willebrand Factor. J Biol Chem. 1991; 266: 22777–22780.

    CAS  PubMed  Google Scholar 

  9. Shelton-Inloes BB, Titani K, Sadler JE. cDNA sequences for human von Willibrand factor reveal five types of repeated domains and five possible protein sequence polymorphisms. Biochemistry. 1986; 25: 3164–3171.

    Article  CAS  PubMed  Google Scholar 

  10. Perez-Vilar JA, Eckhardt E, Hill RL. Porcine submaxillary mucin forms disulfide-bonded dimers between its carboxyl-terminal domains. J Biol Chem. 1996; 271: 9845–9850.

    Article  CAS  PubMed  Google Scholar 

  11. Gipson IK, Ho SB, Spurr-Michaud SJ, et al. Mucin genes expressed by human female reproductive tract epithelia. Biol Reprod. 1997; 56: 999–1011.

    Article  CAS  PubMed  Google Scholar 

  12. Bobek LA, Tsai H, Biesbrock AR, Levine, MJ. Molecular cloning sequence, and specificity of expression of gene encoding the low molecular weight human salivary mucin (MUC7). J Biol Chem. 1993; 268: 20563–20569.

    CAS  PubMed  Google Scholar 

  13. Greiner JV, Weidman TA, Korb DR, Allansmith MR. Histochemical analysis of secretory vesicles in non goblet. conjunctival epithelial cells. Acta Ophthalmol. 1985; 63: 89–92.

    CAS  Google Scholar 

  14. Dilly PN. On the nature and the role of the subsurface vesicles in the outer epithelial cells of the conjunctiva. Br J Ophthalmol. 1985; 69: 477–481.

    Article  CAS  PubMed  Google Scholar 

  15. Jensen OA, Falbe-Hansen I, Jacobsen T, Michelsen A. Mucosubstances of the acini of the human lacrimal gland (orbital part). Act Ophthalmol. 1969; 47: 605–619.

    Article  CAS  Google Scholar 

  16. Kreuger J, Sokoloff N, Botelho SY. Sialic acid in rabbit lacrimal gland fluid. Invest Ophthalmol Vis Sci. 1976; 15: 479–481.

    CAS  Google Scholar 

  17. Allen M, P Wright, Reid L. The human lacrimal gland. A histochemical and organ culture study of the secretory cells. Arch Ophthalmol. 1972; 88: 493–497.

    Article  CAS  PubMed  Google Scholar 

  18. Inatomi T, Spurr-Michaud S, Tisdale AS, Gipson IK. Human corneal and conjunctival epithelia express MUC1 mucin. Invest Ophthalmol Vis Sci. 1995; 36: 1818–1827.

    CAS  PubMed  Google Scholar 

  19. Inatomi T, Spurr-Michaud S, Tisdale AS, Zhan Q, Feldman ST, Gipson IK. Expression of secretory mucin genes by human conjunctival epithelia. Invest Ophthalmol Vis Sci. 1996; 37: 1684–1692.

    CAS  PubMed  Google Scholar 

  20. Ligtenberg MIL, Buijs F, Yos HL, Hilkens J. Suppression of cellular aggregation of high levels of episialin. Cancer Res. 1992; 52: 2318–2324.

    CAS  PubMed  Google Scholar 

  21. Braga VM, Gendler SJ. Modulation of Muc-1 mucin expression in the mouse uterus during the estrus cycle, early pregnancy and placentation. J Cell Sci. 1993; 105: 397–405.

    CAS  PubMed  Google Scholar 

  22. Bolis S, Devine P, Morris CA. Detection and characterization of human ocular surface mucins. ARVO Abstracts. Invest Ophthalmol Vis Sci. 1995; 36: S421.

    Google Scholar 

  23. Jumblatt MM, Geohegan TE, Jumblatt JE. Mucin gene expression in human conjunctiva. ARVO Abstracts. Invest Ophthalmol Vis Sci. 1995; 36: S997.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1998 Springer Science+Business Media New York

About this chapter

Cite this chapter

Gipson, I.K., Inatomi, T. (1998). Cellular Origin of Mucins of the Ocular Surface Tear Film. In: Sullivan, D.A., Dartt, D.A., Meneray, M.A. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes 2. Advances in Experimental Medicine and Biology, vol 438. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5359-5_32

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-5359-5_32

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7445-9

  • Online ISBN: 978-1-4615-5359-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics