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Voltage- and Ca2+-Dependent Chloride Current Activated by Hyposmotic and Hyperosmotic Stress in Rabbit Superior Lacrimal Acinar Cells

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Lacrimal Gland, Tear Film, and Dry Eye Syndromes 2

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 438))

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Abstract

Tears provide a protective and lubricating film that covers the anterior surface of the eye. The bulk of tears is a salty serous fluid, containing a variety of proteins associated with bacterial defense. In rabbits, tears are produced by the superior and inferior lacrimal glands. Secretion of the serous fluid is dependent on the distribution and nature of ion channels in lacrimal acinar cells.1,2 We have identified a voltage- and Ca2+-dependent outwardly rectifying Cl- (Clor) channel in rabbit superior lacrimal gland acinar cells. The purpose of this study was to evaluate the role of this Clor channel in secretion by the rabbit lacrimal glan dacinar cells.

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References

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Authors and Affiliations

  1. Co-operative Research Centre for Eye Research and Technology, University of New South Wales, Kensington, Australia

    George H. Herok, Thomas J. Millar, Philip JnA Derton & Donald K. Martin

  2. Department of Biological Sciences, University of Western Sydney/Nepean, Australia

    George H. Herok & Thomas J. Millar

  3. School of Optometry, University of New South Wales, Kensington, Australia

    Philip JnA Derton

  4. Department of Biological Sciences, University of Technology, Sydney, New South Wales, Australia

    Donald K. Martin

Authors
  1. George H. Herok
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  2. Thomas J. Millar
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  3. Philip JnA Derton
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  4. Donald K. Martin
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Editor information

Editors and Affiliations

  1. The Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts, USA

    David A. Sullivan  & Darlene A. Dartt  & 

  2. Louisiana State University Medical Center, New Orleans, Louisiana, USA

    Michele A. Meneray

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© 1998 Springer Science+Business Media New York

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Herok, G.H., Millar, T.J., Derton, P.J., Martin, D.K. (1998). Voltage- and Ca2+-Dependent Chloride Current Activated by Hyposmotic and Hyperosmotic Stress in Rabbit Superior Lacrimal Acinar Cells. In: Sullivan, D.A., Dartt, D.A., Meneray, M.A. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes 2. Advances in Experimental Medicine and Biology, vol 438. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5359-5_17

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  • DOI: https://doi.org/10.1007/978-1-4615-5359-5_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7445-9

  • Online ISBN: 978-1-4615-5359-5

  • eBook Packages: Springer Book Archive

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