Abstract
Lacrimal gland secretory activity is important for maintaining a healthy ocular mucosa.1,2 Lacrimal glands in rodents and other species including humans show histomorphological and biochemical sexual dimorphisms.3–6 Moreover, in humans, lacrimal gland secretory insufficiency leading to dry eyes (keratoconjunctivitis sicca) is known to predominantly afflict women.5 The hormonal regulation of this gland and its secretory activity has been investigated mainly in the rat, where marked histomorphological sex differences and higher levels of secretory component and IgA in male gland and tears have been attributed to the inductive effect of androgens on protein synthesis.7 Such effects are likely to be mediated via androgen receptors in the lacrimal gland.7 Unlike androgens, estrogens are believed to have no effect on the lacrimal gland.7
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References
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De, P.K., Ranganathan, V. (1998). Hormonal Influences on Syrian Hamster Lacrimal Gland. In: Sullivan, D.A., Dartt, D.A., Meneray, M.A. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes 2. Advances in Experimental Medicine and Biology, vol 438. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5359-5_10
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DOI: https://doi.org/10.1007/978-1-4615-5359-5_10
Publisher Name: Springer, Boston, MA
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