Abstract
The BW tumor model consists of variants that were derived from the AKR (H-2k) T-cell lymphoma BW 5147 [1] and for which a correlation was found between expression of MHC class I antigens and malignancy. In particular, H-2Kk antigens were found to function as classical restriction elements, presenting antigenic peptides to CD8 + cytotoxic T cells (CTLs). Hence, an increased expression of H-2Kk is correlated with an increased immunogenicity of the BW cancer cells, resulting in a reduced tumor growth and metastatic potential upon subcutaneous (s.c.) inoculation. [2].
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Abbreviations
- β2m:
-
β2-microglobulin
- CTL:
-
cytotoxic T lymphocyte
- FACS:
-
Fluorescence Activated Cell Sorting
- IFN-γ:
-
interferon-gamma
- LMP:
-
Low Molecular mass Protein
- MHC:
-
Major Histocompatibility Complex
- RT-PCR:
-
reverse transcription/ polymerase chain reaction
- s.c:
-
subcutaneous
References
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Raes, G., Van Ginderachter, J., Devoogdt, N., Geldhof, A., De Baetselier, P. (1998). Effects of Altered Antigen Processing on T-Cell Responses Toward Murine T-Lymphomas. In: Walden, P., Trefzer, U., Sterry, W., Farzaneh, F., Zambon, P. (eds) Gene Therapy of Cancer. Advances in Experimental Medicine and Biology, vol 451. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5357-1_33
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DOI: https://doi.org/10.1007/978-1-4615-5357-1_33
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