Abstract
Mice from most inbred strains (e.g., C3H, CBA, C57BL/6) are resistant to infection with Leishmania major, an obligate intracellular parasite of macrophages in the mammalian host. In contrast, mice from BALB strains are unable to control infection and develop progressive disease. Resistance and susceptibility have been correlated with the appearance of parasite-specific Th1 or Th2 cells, respectively(1). Furthermore, the passive transfer of L. major-specific Th1 or Th2 cells has alone conferred resistance or susceptibility to immunodeficient mice(2), strongly suggesting that by themselves these cells mediate either resistance or susceptibility to infection with this parasite.
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Louis, J.A., ConceiƧao-Silva, F., Himmelrich, H., Tacchini-Cottier, F., Launois, P. (1998). Anti-Leishmania Effector Functions of CD4+ Th1 Cells and Early Events Instructing Th2 Cell Development and Susceptibility to Leishmania Major in BALB/c Mice. In: Gupta, S., Sher, A., Ahmed, R. (eds) Mechanisms of Lymphocyte Activation and Immune Regulation VII. Advances in Experimental Medicine and Biology, vol 452. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5355-7_7
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DOI: https://doi.org/10.1007/978-1-4615-5355-7_7
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