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Dynamics of the CD8+ T Cell Response during Acute LCMV Infection

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Mechanisms of Lymphocyte Activation and Immune Regulation VII

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 452))

Abstract

CD8+ T cells are normally less numerous than CD4+ T cells in uninfected individuals. Virus infections can result in an especially intense activation of CD8+ T cells1–5 and there are large increases in the number of circulating CD8+ T cells in humans infected with cytomegalovirus, Epstein-Barr Virus, or Varicella-Zoster Virus.1,3,4 In mice infected with LCMV there is an approximately 5-fold increase in the number of CD8+ T cells.6 As the total number of CD8+ cells expands, limiting dilution analysis (LDA) reveals that the number of virus specific CTL also increases.5–8 However, LDA indicates that the number of virus-specific CD8+ T cells is small, 1/4000-1/50 depending upon the virus.5–8 The specificities of the rest of the expanding CD8+ T cells has not been determined, though it has been shown that during LCMV infection there is an increase in non-LCMV reactive CTL that are alloreactive and antigen crossreactive CTL.9,10 Furthermore, there are not only more CD8+ T cells during the immune response to LCMV, but most of them appear to have been activated as they are enlarged, have elevated surface expression of CD11a, CD11b, CD44, CD49d, IL-2R and reduced expression of CD62L.11–13

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Authors and Affiliations

  1. Howard Hughes Medical Institute and Department of Immunology, University of Washington, Box 357370, Seattle, Washington, 98195, USA

    Eric Butz & Michael J. Bevan

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  1. Eric Butz
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Editors and Affiliations

  1. University of California, Irvine, Irvine, California, USA

    Sudhir Gupta

  2. National Institutes of Health, Bethesda, Maryland, USA

    Alan Sher

  3. Emory University, Atlanta, Georgia, USA

    Rafi Ahmed

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© 1998 Springer Science+Business Media New York

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Butz, E., Bevan, M.J. (1998). Dynamics of the CD8+ T Cell Response during Acute LCMV Infection. In: Gupta, S., Sher, A., Ahmed, R. (eds) Mechanisms of Lymphocyte Activation and Immune Regulation VII. Advances in Experimental Medicine and Biology, vol 452. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5355-7_13

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  • DOI: https://doi.org/10.1007/978-1-4615-5355-7_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7443-5

  • Online ISBN: 978-1-4615-5355-7

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