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Physical Characterization and Stability of a Microemulsion for Potential Oral Administration of a Peptide

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Biomedical Science and Technology

Abstract

Over the past few years, much attention has been paid to potential pharmaceutical uses of microemulsions as novel drug delivery systems. Microemulsions are defined as multicomponent systems consisting a unique ratio of component including a lipophilic phase, a hydrophilic phase, a surfactant and a co-surfactant1. Main characteristics of this system are low viscosity, isotropicity, thermodynamically stability2 and droplet diameter less than 100 nm3. Such systems are formed spontaneously3,4. The use of microemulsions as possible therapeutic systems is interesting for two main reasons: a) controlled drug release5, b) increased systemic and topical absorption of drugs4,6,7.

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References

  1. H.N. Bhargava, A. Narurkar, and L.M. Lieb, Using microemulsions for drug delivery, Pharm. Techhol 11(3): 46–54(1987).

    CAS  Google Scholar 

  2. J.M. Sarciaux, AR. Hilgers, A.M. Cooper, K.J. Cook, P.S. Burton and M.V. Patel, Oral absorption potential of peptidic drugs from microemulsion formulations: A case study of U-71038, B.T. Gattefossé, 88: 11–19 (1995).

    Google Scholar 

  3. A. Meinzer, E. Mueller and J. Vonderscher, Microemulsion a suitable galenical approach for the absorption enhancement of low soluble compounds, B. T Gattefossé, 88: 21–26(1995).

    Google Scholar 

  4. W.A. Ritschel, Microemulsions for improved peptide absorption from the gastrointestinal tract, Meth. Find. Exp. Clin.Pharmacol 13 (3):205–220(1991).

    CAS  Google Scholar 

  5. R. Wallin, H. Dyhre, S. Björkman, A. Fyge, S. Engström and H. Renck, Prolongation of lidocaine induced regional anesthesia by a slow-release microemulsion formulation, Proceed.Int’I. Symp. Control. Rel. Bioact. Mater, 24, 555–556(1997).

    Google Scholar 

  6. P.P. Constantinidis, J-P. Scalari, C. Lancaster, J. Marcello, G. Marks, H. Ellens and P.L. Smith, Formulation and intestinal absorption enhancement evaluation of water-in-oil microemulsions in corporating medium-chain glycerides, Pharm. Res.,11(10), 1385–1390 (1994).

    Article  Google Scholar 

  7. F. Février, M.F. Bobin, C. Lafforgue and M.C. Martini, Advances in microemulsions and transepidermal penetration of tyrosine, S.T.P. Pharma Sciences, 1 (1):60–63(1991).

    Google Scholar 

  8. V.H.L. Lee, S. Dodda-Kashi, G.M. Grass and W. Rubes, Oral route of peptide and protein drug delivery, in:Peptide and Protein Drug Delivery, V.H.L. Lee, ed., Marcel Decker Inc., New York, 691–738(1991).

    Google Scholar 

  9. V.H.L. Lee, Changing needs in drug delivery in the era of peptide and protein drugs, in:Peptide and Protein Drug Delivery, V.H.L. Lee, ed., Marcel Decker Inc., New York, 1–56(1991).

    Google Scholar 

  10. V.H.L. Lee, R.D. Traver and M.E. Taub, Enzymatic barriers to peptide and protein drug delivery, in: Peptide and Protein Drug Delivery, V.H.L. Lee, ed.. Marcel Decker Inc., New York, 303–358(1991).

    Google Scholar 

  11. M. Lynda, M. Sanders, Controlled delivery systems for peptides, in: Peptide and Protein Drug Delivery, V.H.L. Lee, ed., Marcel Decker Inc., New York, 785–806(1991).

    Google Scholar 

  12. K. Takada, N. Shibata, H. Yoshimura, Y. Masuda, H. Yoshikawa, S. Muranishi, and T. Oka, Promotion of the selective lymphatic delivery of cyclosporin A by lipid-surfactant mixed micelles, J. Pharmacobio-Dyn 8: 320–323(1985).

    Article  PubMed  CAS  Google Scholar 

  13. J.P. Reymond, H. Sucker and J. Vonderscher, In vivo model for cyclosporin intestinal absorption in lipid vehicles, Pharm.Res, 5: 677–679(1988).

    Article  PubMed  CAS  Google Scholar 

  14. B.D. Tarr, and S.H. Yalkowsky, Enhanced intestinal absorption of cyclosporine in rats through the reduction of emulsion droplet size, Pharm. Res, 6: 40–43(1989).

    Article  PubMed  CAS  Google Scholar 

  15. W.A. Ritschel, S. Adolph, G.B. Ritschel and T. Schroeder, Improvement of peroral absorption of cyclosporine A by microemulsions, Meth. Find. Exp. Clin. Pharmacol, 12(2), 127–134(1990).

    CAS  Google Scholar 

  16. R. Aboofazeli and M.J. Lawrence, Incestigations into the formation and characterization of phospholipid microemulsions. I. Pseudo-ternary phase diagrams of systems containing water-lecithin-alcohol-isopropyl myristate, Int. J. Pharm, 93, 161–175(1993).

    Article  CAS  Google Scholar 

  17. R.C. Baker, A.T. Florence, R.H. Ottewill and F. Tadros, Investigations into the formation and characterization of microemulsions II. Light scattering conductivity and viscosity studies of microemulsions, J. Coll. Int. Sci, 100(2), 332–349(1984).

    Article  CAS  Google Scholar 

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Türkyılmaz, A., Çelebi, N., Gönül, B., Alkan-Önyüksel, H. (1998). Physical Characterization and Stability of a Microemulsion for Potential Oral Administration of a Peptide. In: Hıncal, A.A., Kaş, H.S. (eds) Biomedical Science and Technology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5349-6_6

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  • DOI: https://doi.org/10.1007/978-1-4615-5349-6_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7440-4

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