Abstract
Over the past few years, much attention has been paid to potential pharmaceutical uses of microemulsions as novel drug delivery systems. Microemulsions are defined as multicomponent systems consisting a unique ratio of component including a lipophilic phase, a hydrophilic phase, a surfactant and a co-surfactant1. Main characteristics of this system are low viscosity, isotropicity, thermodynamically stability2 and droplet diameter less than 100 nm3. Such systems are formed spontaneously3,4. The use of microemulsions as possible therapeutic systems is interesting for two main reasons: a) controlled drug release5, b) increased systemic and topical absorption of drugs4,6,7.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
H.N. Bhargava, A. Narurkar, and L.M. Lieb, Using microemulsions for drug delivery, Pharm. Techhol 11(3): 46–54(1987).
J.M. Sarciaux, AR. Hilgers, A.M. Cooper, K.J. Cook, P.S. Burton and M.V. Patel, Oral absorption potential of peptidic drugs from microemulsion formulations: A case study of U-71038, B.T. Gattefossé, 88: 11–19 (1995).
A. Meinzer, E. Mueller and J. Vonderscher, Microemulsion a suitable galenical approach for the absorption enhancement of low soluble compounds, B. T Gattefossé, 88: 21–26(1995).
W.A. Ritschel, Microemulsions for improved peptide absorption from the gastrointestinal tract, Meth. Find. Exp. Clin.Pharmacol 13 (3):205–220(1991).
R. Wallin, H. Dyhre, S. Björkman, A. Fyge, S. Engström and H. Renck, Prolongation of lidocaine induced regional anesthesia by a slow-release microemulsion formulation, Proceed.Int’I. Symp. Control. Rel. Bioact. Mater, 24, 555–556(1997).
P.P. Constantinidis, J-P. Scalari, C. Lancaster, J. Marcello, G. Marks, H. Ellens and P.L. Smith, Formulation and intestinal absorption enhancement evaluation of water-in-oil microemulsions in corporating medium-chain glycerides, Pharm. Res.,11(10), 1385–1390 (1994).
F. Février, M.F. Bobin, C. Lafforgue and M.C. Martini, Advances in microemulsions and transepidermal penetration of tyrosine, S.T.P. Pharma Sciences, 1 (1):60–63(1991).
V.H.L. Lee, S. Dodda-Kashi, G.M. Grass and W. Rubes, Oral route of peptide and protein drug delivery, in:Peptide and Protein Drug Delivery, V.H.L. Lee, ed., Marcel Decker Inc., New York, 691–738(1991).
V.H.L. Lee, Changing needs in drug delivery in the era of peptide and protein drugs, in:Peptide and Protein Drug Delivery, V.H.L. Lee, ed., Marcel Decker Inc., New York, 1–56(1991).
V.H.L. Lee, R.D. Traver and M.E. Taub, Enzymatic barriers to peptide and protein drug delivery, in: Peptide and Protein Drug Delivery, V.H.L. Lee, ed.. Marcel Decker Inc., New York, 303–358(1991).
M. Lynda, M. Sanders, Controlled delivery systems for peptides, in: Peptide and Protein Drug Delivery, V.H.L. Lee, ed., Marcel Decker Inc., New York, 785–806(1991).
K. Takada, N. Shibata, H. Yoshimura, Y. Masuda, H. Yoshikawa, S. Muranishi, and T. Oka, Promotion of the selective lymphatic delivery of cyclosporin A by lipid-surfactant mixed micelles, J. Pharmacobio-Dyn 8: 320–323(1985).
J.P. Reymond, H. Sucker and J. Vonderscher, In vivo model for cyclosporin intestinal absorption in lipid vehicles, Pharm.Res, 5: 677–679(1988).
B.D. Tarr, and S.H. Yalkowsky, Enhanced intestinal absorption of cyclosporine in rats through the reduction of emulsion droplet size, Pharm. Res, 6: 40–43(1989).
W.A. Ritschel, S. Adolph, G.B. Ritschel and T. Schroeder, Improvement of peroral absorption of cyclosporine A by microemulsions, Meth. Find. Exp. Clin. Pharmacol, 12(2), 127–134(1990).
R. Aboofazeli and M.J. Lawrence, Incestigations into the formation and characterization of phospholipid microemulsions. I. Pseudo-ternary phase diagrams of systems containing water-lecithin-alcohol-isopropyl myristate, Int. J. Pharm, 93, 161–175(1993).
R.C. Baker, A.T. Florence, R.H. Ottewill and F. Tadros, Investigations into the formation and characterization of microemulsions II. Light scattering conductivity and viscosity studies of microemulsions, J. Coll. Int. Sci, 100(2), 332–349(1984).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1998 Springer Science+Business Media New York
About this chapter
Cite this chapter
Türkyılmaz, A., Çelebi, N., Gönül, B., Alkan-Önyüksel, H. (1998). Physical Characterization and Stability of a Microemulsion for Potential Oral Administration of a Peptide. In: Hıncal, A.A., Kaş, H.S. (eds) Biomedical Science and Technology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5349-6_6
Download citation
DOI: https://doi.org/10.1007/978-1-4615-5349-6_6
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-7440-4
Online ISBN: 978-1-4615-5349-6
eBook Packages: Springer Book Archive