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Biomedical Science and Technology pp 189–196Cite as

Vancomycin-Loaded Calcium Sulfate for the Treatment of Osteomyelitis — Controlled Release by a Poly(Lactide-Co-Glycolide) Polymer

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Abstract

Despite the availability of more recent antimicrobial agents, the treatment of bone diseases like osteomyelitis, caused by microbial infection remains an important orthopaedic problem. The characteristics of bone make chronic osteomyelitis refractory. Hard walls surround the soft tissues of bone and inflammation of the contained tissues causes circulatory disturbances which can readily lead to necrosis of various parts of the bone. These anatomical features provide an environment suited for the localization and colonization by bacteria1. Then, the surgical removal of necrotic tissues and the antibiotic administration are the primary methods of treatment of chronic osteomyelitis2. Necrotic bone provides an appropriate surface for the development of a biofilm3 and the causative bacteria produce large amount of extracellular fibrous glycocalyx materials4. Therefore, the antibiotic concentration must be many times higher than the MIC (Minimum Inhibitory Concentration) to eradicate bacteria encased in this biofilm5. This may be one reason why the disease is uneasy to treat even though the penetration of some antibiotics into infected bone is higher than into normal bone6.

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Authors and Affiliations

  1. Ecole de Pharmacie, Laboratoire de Pharmacie Galénique Industrielle & Officinale, Université Catholique de Louvain, Av. E. Mounier 73.20, 1200, Bruxelles, Belgium

    Marie-Ange Benoit, Benoît Mousset & Jean Gillard

  2. Clinique Europe, St Michel - Square Marie-Louise 59, 1040, Bruxelles, Belgium

    Richard Bouillet

  3. Cliniques Universitaires St-Luc Service d’Orthopédie, Av. Hippocrate 10, 1200, Bruxelles, Belgium

    Christian Delloye

Authors
  1. Marie-Ange Benoit
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  2. Benoît Mousset
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  3. Richard Bouillet
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  4. Christian Delloye
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  5. Jean Gillard
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Editors and Affiliations

  1. Hacettepe University, Ankara, Turkey

    A. Atilla Hıncal  & H. Süheyla Kaş  & 

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Benoit, MA., Mousset, B., Bouillet, R., Delloye, C., Gillard, J. (1998). Vancomycin-Loaded Calcium Sulfate for the Treatment of Osteomyelitis — Controlled Release by a Poly(Lactide-Co-Glycolide) Polymer. In: Hıncal, A.A., Kaş, H.S. (eds) Biomedical Science and Technology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5349-6_21

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  • DOI: https://doi.org/10.1007/978-1-4615-5349-6_21

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7440-4

  • Online ISBN: 978-1-4615-5349-6

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