Abstract
Abnormal levels of cytokines, including interleukin-6 (IL-6), are found in the cere brospinal fluid and brain of individuals infected with the human immunodeficiency virus (HIV)6,16,19 and may contribute to the central nervous system (CNS) pathology and cognitive dysfunction observed in individuals with NeuroAIDS. Consistent with this possibility, transgenic mice that overexpress IL-6 (IL-6 transgenic mice) in the CNS show CNS pathology that resembles the neuropathology observed in HIV-infected individuals12. Moreover, electrophysiological investigations of the IL-6 transgenic mice indicate that the functional properties of CNS neurons13 and neuronal circuits3,17 are altered by IL-6 overexpression in the CNS, and behavioral studies show that cognitive deficits occur as well8.
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Gruol, D.L., Sweeney, D.D., Conroy, S.M., Trotter, C., Netzeband, J.G., Qiu, Z. (1998). Cannabinoids Alter Neurotoxicity Produced by Interleukin-6 in Central Nervous System Neurons. In: Friedman, H., Madden, J.J., Klein, T.W. (eds) Drugs of Abuse, Immunomodulation, and Aids. Advances in Experimental Medicine and Biology, vol 437. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5347-2_26
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DOI: https://doi.org/10.1007/978-1-4615-5347-2_26
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