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FIV

A Lentivirus Model for Opiate Effects on Disease

  • Chapter
Drugs of Abuse, Immunomodulation, and Aids

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 437))

Abstract

Drug abuse is currently a main route of exposure to HIV-1. However, the role that opiates play in lentivirus neurologic disease progression remains unclear. There is a pressing need for appropriate animal models to examine the role of opiates on lentivirus disease progression, particularly the CNS form of the disease. The FIV/cat model has now been developed as a legitimate system for the study of lentivirus induced neurologic disease. Not only does FIV produce a disease that is very similar to human AIDS, but it is also similar to HIV at both the molecular and biochemical levels. In this article, we will first review interactions of opiates with HIV-1 and the immune system, and then progress into a discussion of FIV and its value as a potential model.

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  1. The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California, 92037, USA

    Jean-Noel Billaud & Tom R. Phillips

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Billaud, JN., Phillips, T.R. (1998). FIV. In: Friedman, H., Madden, J.J., Klein, T.W. (eds) Drugs of Abuse, Immunomodulation, and Aids. Advances in Experimental Medicine and Biology, vol 437. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5347-2_12

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