Abstract
Membrane-bound AChE is widely used for the estimation of the inhibitory activity of various agents studied in AD therapy. The interpretation of both results is of great importance for clinical study and application of new drugs. Antioxidants (AO) inhibitors of free radical processes, present a promising group of compounds for AD treatment. We investigated the action of some AO on the kinetic properties of membrane-bound AChE of human erythrocytes and rat brain synaptosomes.
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Braginskaya, F. I., Molochkina, E. M., Zorina, O. M., Ozerova, I. B., and Burlakova, E. B., 1996, New synthetic bioantioxidants—acetylcholinesterase (AChE) inhibitors, in: Alzheimer Disease: From Molecular Biology to Therapy, Becker, R..and Giacobini, E., eds., Birkhauser-Boston, p. 337–342.
Burlakova, E. B., 1994, Antioxidant drugs as neuroprotective agents. In: Alzheimer Disease: Therapeutic Strategies, Giacobini E., and Becker R., eds., Birkhauser: Boston, p. 313–317.
Cuadra, G., Summers, K., and Giacobini, E., 1994, Cholinesterase inhibitor effects on neurotransmitters in rat cortex in vivo. J. Pharmacol. Exp. Ther 270:277–284.
Ellman, g. L., Courtney, K. D., Andres, V., Jr., and Featherstone, R. M., 1961, A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem. Pharmacol. 7:88–96.
Gray, E. G., and Whittaker, V. P., 1962, Isolation of nerve endings from brain: an electron microscopic study of cell fragments derived by homogenization and centrifugation. J.Anat. 96:79–88.
Lowry, O. H., Rosebrough, N. J., Farr, A. K., and Randall, R.J., 1951, Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:265–275.
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Braginskaya, F.I., Molochkina, E.M., Zorina, O.M., Ozerova, I.B., Burlakova, E.B. (1998). Comparative Study of Antioxidants’ Action on Membrane-Bound Acetylcholinesterase (AChE) of Blood Erythrocytes and Brain Synaptosomes. In: Fisher, A., Hanin, I., Yoshida, M. (eds) Progress in Alzheimer’s and Parkinson’s Diseases. Advances in Behavioral Biology, vol 49. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5337-3_25
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DOI: https://doi.org/10.1007/978-1-4615-5337-3_25
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