Abstract
The central core of the hypothesis underlying the present chapter is that terminally differentiated cells like neurons that have irreversibly exited the cell cycle have acquired programmed cell death (apoptosis) as an alternative effector pathway. This pathway may be activated in response to molecular events that lead to transformation of dividing stem cell populations. For example, alterations of those genes that can cause transformation in dividing cell populations, can cause apoptosis of terminally differentiated neurons. Up to now, it is quite evident that apoptosis is an important component in many progressive and acute neurodegenerative diseases. The extracellular signals as well as the intracellular mechanisms inducing and regulating apoptosis (or different types of apoptosis) of neuronal cells are still a matter of investigation.
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Uberti, D. et al. (1998). Common Mechanisms in Cell Cycle and Cell Death. In: Fisher, A., Hanin, I., Yoshida, M. (eds) Progress in Alzheimer’s and Parkinson’s Diseases. Advances in Behavioral Biology, vol 49. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5337-3_13
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DOI: https://doi.org/10.1007/978-1-4615-5337-3_13
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