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Genesis of Topographic and Cellular Diversity in the Primate Retina

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Development and Organization of the Retina

Part of the book series: NATO ASI Series ((NSSA,volume 299))

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Abstract

The retina in the developing macaque monkey is an unexcelled model system for the analysis of cellular events and the mechanisms that govern formation of the human eye. Application of the powerful methods of modern neurobiology applied to either normal embryos, or mature animals with altered visual systems, suggests that the emergence of cell classes and their segregation into primate-specific functional domains emerges as a result of multiple factors operating at each retinal layer during successive developmental stages. The available data are compatible with the hypothesis that, at early developmental stages, intrinsic mechanisms operating within the retina predominate, while at later stages reciprocal interactions with the visual centers refines the numerical cellular relationships and synaptic architecture. These studies may provide insight into the development of normal and abnormal vision in humans.

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Authors and Affiliations

  1. Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut, 06510, USA

    Pasko Rakic M.D., Sc.D.

  2. Section of Neurobiology, Yale University School of Medicine, P.O. Box 208001, New Haven, CT, 06520-8001, USA

    Pasko Rakic M.D., Sc.D.

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  1. Pasko Rakic M.D., Sc.D.
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Editors and Affiliations

  1. University of California at Davis, Davis, California, USA

    Leo M. Chalupa

  2. Cornell University, Ithaca, New York, USA

    Barbara L. Finlay

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Rakic, P. (1998). Genesis of Topographic and Cellular Diversity in the Primate Retina. In: Chalupa, L.M., Finlay, B.L. (eds) Development and Organization of the Retina. NATO ASI Series, vol 299. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5333-5_5

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