Abstract
Recently, cloning and sequencing of cDNAs and genes encoding animal and plant lipoxygenases has demonstrated that these enzymes are evolutionary related (1). Lipoxygenases catalyze stereospecific insertion of molecular oxygen into polyunsaturated fatty acids to form primary lipoxygenase products e.g. hydr(oper)oxyeicosatetraenoic acids (H(P)ETEs) (2). Secondary lipoxy genase products (e.g. leukotrienes) formed by arachidonate 5-lipoxygenase in conjunction with other enzymes play pivotal roles in the pathogenesis of allergic and inflammatory diseases (3). The biological functions of primary lipoxygenase products (5-, 12-, and 15-H(P)ETEs) are less well understood. Yet these compounds are often formed more abundantly than are the secondary lipoxygenase products.
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References
Toh, H., Yokoyama, C., Tanabe, T., Yoshimoto, T. and Yamamoto, S. Prostaglandins 44:291–315, 1992.
Yamamoto, S. Free Radic. Biol. Med. 10:149–159, 1991.
Samuelsson, B., Dahlen, S.-E., Lindgren, J.Å., Rouzer, C.A. and Serhan, C. N. Science 237:1171–1176, 1987.
Hamberg, M. and Samuelsson, B. Proc. Natl. Acad. Sci. USA 71:3400–3404, 1974.
Hammarström, S., Hamberg, M., Samuelsson, B., Duell, E.A., Stawiski, M. and Voorhees, J. J. Proc. Natl. Acad. Sci. USA 72:5130–5134, 1975.
Ruzicka, T. Eicosanoids Suppl. 5, S63-S65, 1992.
Piomelli, D., Volterra, A., Dale, N., Siegelbaum, S.A., Kander, E.R., Schwartz, J.H. and Belardetti, F. Nature 328:38–43, 1987.
Sekiya, F., Takagi, J., Usui, T., Kawajiri, K., Kobayashi, Y., Sato, F. and Saito, Y. Biochem. Biophys. Res. Commun. 179:345–351, 1991.
Honn, K.V., Grossi, I.M., Fitzgerald, L.A., Umbarger, L.A., Diglio, C.A. and Taylor, J.D. Proc. Soc. Exp. Biol. Med. 189:130–135, 1988.
Liotta, L.A. Sci. Am. 266:34–41, 1992.
Johnson, J.P., Stade, B.G., Holzmann, B., Schwäble, W. and Riethmüller, G. Proc. Natl. Acad. Sci. USA 86:641–644, 1989.
Herbertsson, H. and Hammarström, S. FEBS Letters 298:249–252, 1992.
Folch, J., Lees, M. and Sloane-Stanley, G.H. J. Biol. Chem. 226:497–509, 1957.
Herbertsson, H. and Hammarström, S. (1993) Submitted to Proc. Natl. Acad. Sci. USA.
Moldéus, P., Högberg, J. and Orrenius, S. Methods Enzymol. 52:60–71, 1978.
Heppel, L.A. and Hilmoe, R.J. Methods Enzymol. 2:546–550, 1955.
Chen, P.S., Toribara, T.Y. and Warner, H. Anal. Chem. 28:1756–1758, 1956.
Green, D.E., Mii, S. and Kohout, P.M. J. Biol. Chem. 217:551–567, 1955.
Widnell, C.C. and Tata, J.R. Biochem. J. 92:313–317, 1964.
Brunk, C.F., Jones, K.C. and James, T.W. Anal. Biochem. 92:497–500, 1979.
Sanchez, E.R., Meshinchi, S., Tienrungroj, W., Schlesinger, M.J., Toft, D. O. and Pratt, W.B. J. Biol. Chem. 262:6986–6991, 1987.
Hoeck, W. and Groner, B. J. Biol. Chem. 265:5403–5408, 1990.
Sugimoto, Y., Namba, T., Honda, A., Hayashi, Y., Negishi, M., Ichikawa, A. and Narumiya, S. J. Biol. Chem. 267:6463–6466, 1992.
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Herbertsson, H., Hammarström, S. (1997). Cytosolic 12(S)-Hydroxy-5,8,10,14-Eicosatetraenoic Acid Binding Sites in Carcinoma Cells. In: Honn, K.V., Nigam, S., Marnett, L.J. (eds) Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury 2. Advances in Experimental Medicine and Biology, vol 400. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5325-0_41
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DOI: https://doi.org/10.1007/978-1-4615-5325-0_41
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