Abstract
Prostaglandin E2 (PGE2) is a potent modulator of a wide variety of physiological responses including inflammation (1), gastric acid secretion (2), vascular tone (3), lipolysis (4) and water and ion transport (5). The rabbit kidney represents a well characterized physiological model with respect to PGE2 effects. In the kidney, PGE2 has been shown to modulate glomerular hemodynamics (6) as well as water and ion transport in the thick ascending limb (7) and collecting duct. Under some circumstances the cellular effects of PGE2 appear to be self-opposing. In the cortical collecting duct (CCD), PGE2 causes stimulation of water reabsorption via increasing the intracellular level of cAMP (8,9) and suppression of arginine-vasopressin water reabsorption by inhibiting cAMP generation (8). Similarly PGE2 has been shown to vasodilate certain vascular beds while it constricts other vascular beds (10,11,12). These self-opposing effects of PGE2 appear to be mediated by separate classes of PGE2 receptors (3).
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Breyer, R.M., Emeson, R.B., Davis, L.S., Breyer, M.D. (1997). Structure and Localization of the Rabbit Prostaglandin EP3 Receptor. In: Honn, K.V., Nigam, S., Marnett, L.J. (eds) Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury 2. Advances in Experimental Medicine and Biology, vol 400. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5325-0_38
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DOI: https://doi.org/10.1007/978-1-4615-5325-0_38
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