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Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury 2 pp 247–251Cite as

LTB4 Receptor Antagonists Exacerbate T Lymphocyte-Mediated Delayed Hypersensitivity in Guinea Pigs

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 400))

Abstract

Leukotriene B4 (LTB4) is a potent lipid mediator of many inflammatory processes (1,2). In addition, elevated tissue levels of LTB4 have been reported in inflammatory diseases such as psoriasis (3) and inflammatory bowel disease (4). For these reasons, LTB4 antagonists have been developed for the treatment of several inflammatory diseases with the aim of inhibiting LTB4 receptor-mediated neutrophil functions (5–7).

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Author information

Authors and Affiliations

  1. Department of Physiology, New York Medical College, Valhalla, NY, 10595, USA

    Patrick Y-K Wong

  2. Department of Experimental Pathology, New York Medical College, Valhalla, NY, 10595, USA

    King-Teh Lin

  3. Department of Medicine, New York Medical College, Valhalla, NY, 10595, USA

    Patrick Y-K Wong & Henry P. Godfrey

Authors
  1. Patrick Y-K Wong
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  2. King-Teh Lin
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  3. Henry P. Godfrey
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Editor information

Editors and Affiliations

  1. Wayne State University, Detroit, Michigan, USA

    Kenneth V. Honn

  2. Free University Berlin, Berlin, Germany

    Santosh Nigam

  3. Vanderbilt University, Nashville, Tennessee, USA

    Lawrence J. Marnett

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© 1997 Springer Science+Business Media New York

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Wong, P.YK., Lin, KT., Godfrey, H.P. (1997). LTB4 Receptor Antagonists Exacerbate T Lymphocyte-Mediated Delayed Hypersensitivity in Guinea Pigs. In: Honn, K.V., Nigam, S., Marnett, L.J. (eds) Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury 2. Advances in Experimental Medicine and Biology, vol 400. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5325-0_36

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  • DOI: https://doi.org/10.1007/978-1-4615-5325-0_36

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7430-5

  • Online ISBN: 978-1-4615-5325-0

  • eBook Packages: Springer Book Archive

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