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Applications of Antisense Therapies to Restenosis pp 141–151Cite as

Non-G-Quartet, Non-Sequence Specific Antirestenotic Effects Of Phosphorothioate Oligodeoxynucleotides

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Part of the book series: Perspectives in Antisense Science ((DARE,volume 3))

Abstract

Phosphorothioate oligodeoxynucleotides (PS ODNs) are isoelectronic congeners of phosphodiester oligonucleotides (1). These compounds are nuclease resistant, soluble in aqueous solution, and capable of engaging in Watson-Crick base pair hybridization (1). PS ODNs directed against various protooncogenes such as c-myb and c-myc involved in vascular smooth muscle cell (SMC) proliferation have been employed in sequence-specific antisense strategies to inhibit restenosis after balloon injury (2). Several studies have demonstrated that PS ODNs inhibit in vitro vascular SMC proliferation (3–8). In one study, there was sustained inhibition of SMC proliferation lasting several days after only a single two hour exposure to antisense nonmuscle myosin heavy chain and c-myb oligonucleotides (8). Furthermore, PS ODNs have inhibited restenosis after balloon injury in the rat carotid artery and porcine models (4,5,9).

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Authors and Affiliations

  1. Division of Cardiology, Department of Medicine Columbia-Presbyterian Medical Center, Columbia University College of Physicians & Surgeons, New York, NY, USA

    LeRoy E. Rabbani MD, Alan D. Simon MD & Weizheng Wang MD

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  1. LeRoy E. Rabbani MD
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  2. Alan D. Simon MD
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  3. Weizheng Wang MD
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Editors and Affiliations

  1. Cardiology Division, Columbia University College of Physicians and Surgeons, New York, NY, USA

    LeRoy E. Rabbani M.D. (Assistant Professor of Medicine) (Assistant Professor of Medicine)

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Rabbani, L.E., Simon, A.D., Wang, W. (1999). Non-G-Quartet, Non-Sequence Specific Antirestenotic Effects Of Phosphorothioate Oligodeoxynucleotides. In: Rabbani, L.E. (eds) Applications of Antisense Therapies to Restenosis. Perspectives in Antisense Science, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5183-6_9

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  • DOI: https://doi.org/10.1007/978-1-4615-5183-6_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7361-2

  • Online ISBN: 978-1-4615-5183-6

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