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Microvascular Endothelial Dysfunction after Heart Transplantation

  • Giuseppe Vassalli
  • Augusto Gallino
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 213)

Abstract

The development of graft coronary artery disease is one of the most discouraging aspects in heart transplantation [1, 2, 3, 4]. It is the third leading cause of death (after infection and allograft rejection) in the first year after transplantation, and the first leading cause of death in the subsequent years. Graft vasculopathy is manifested by a unique and unusually accelerated form of coronary artery disease which, in contrast to naturally occurring atherosclerosis, affects the whole length of the coronary vessels, including the small intramural branches [5,6]. Coronary lesions are detected angiographically in 50 percent of patients 5 years after transplantation [5], and intimal thickening can be detected by intravascular ultrasound imaging in a majority of patients with normal coronary angiograms [7,8]. Virtually all 5 year heart transplant survivors have histological evidence of coronary artery disease [6].

Keywords

Myocardial Blood Flow Heart Transplantation Coronary Flow Reserve Cold Pressor Test Cardiac Allograft 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Giuseppe Vassalli
  • Augusto Gallino

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