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Triple Helix Stabilizing Agents

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Triple Helix Forming Oligonucleotides

Part of the book series: Perspectives in Antisense Science ((DARE,volume 2))

Summary

The applications of triple helix forming oligonucleotides can be limited by the relatively low stability of triple helical complexes. Ligands which can bind more tightly to triple helical DNA than to double-helical DNA can stabilize triple helices. This chapter reviews the structural aspects of triple helix ligand complexes and briefly discusses the possible use or role of triple helix stabilizing agents in triplex-based strategies or mechanisms.

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Authors
  1. Christophe Escudé
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  2. Thérèse Garestier
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Editor information

Editors and Affiliations

  1. CNRS, France

    Claude Malvy , Annick Harel-Bellan  & Linda L. Pritchard ,  & 

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© 1999 Springer Science+Business Media New York

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Escudé, C., Garestier, T. (1999). Triple Helix Stabilizing Agents. In: Malvy, C., Harel-Bellan, A., Pritchard, L.L. (eds) Triple Helix Forming Oligonucleotides. Perspectives in Antisense Science, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5177-5_19

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  • DOI: https://doi.org/10.1007/978-1-4615-5177-5_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7358-2

  • Online ISBN: 978-1-4615-5177-5

  • eBook Packages: Springer Book Archive

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