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Growth Hormone and the Immune System

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Growth Hormone

Part of the book series: Endocrine Updates ((ENDO,volume 4))

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Abstract

Growth hormone (GH) and insulin like growth factor I (IGF-I) play an important role in the neuro-endocrine-immune crosstalk. GH and IGF-I receptors are expressed on the surface of immune cells. GH and IGF-I stimulate the proliferation of immunocompetent cells and modulate several humoral and cellular immune functions. In addition, GH and IGF-I are also synthesized and secreted by various immunocompetent cells. Increasing evidence suggests, that the “immune GH-IGF-I axis” acting in a paracrine/autocrine system between the immunocompetent cells has an important function, and at least in part may exert this function autonomously independent of the endocrine system.

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  1. Klinikum Großhadem and Klinikum Innenstadt, Ludwig-Maximilians-Universität, Munich, Germany

    Christoph J. Auernhammer, Martin Bidlingmaier & Christian J. Strasburger

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  1. Christoph J. Auernhammer
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  2. Martin Bidlingmaier
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  1. Sahlgrenska University Hospital, Göteborg, Sweden

    Bengt-Åke Bengtsson M.D.

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Auernhammer, C.J., Bidlingmaier, M., Strasburger, C.J. (1999). Growth Hormone and the Immune System. In: Bengtsson, BÅ. (eds) Growth Hormone. Endocrine Updates, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5163-8_13

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