Abstract
In view of the surprises in bone biology and osteoporosis research over the last two decades, one might consider predicting the future as a new definition of “chutzpah”. However, it is worthwhile to consider how the many exciting new findings in our field might be applied in the future. This is likely to occur in three areas; (1) understanding and manipulating genes, (2) manipulating and modifying systemic and local hormones, and (3) manipulating and transferring bone cells. A large number of factors such as bone morphogenetic proteins (BMP’s, reviewed by Drs. Gamer and Rosen in chapter 2) have been identified as regulators of bone cell function but have turned out to be multifunctional, affecting other mesenchymal tissues. On the other hand, knockout and over expression studies have provided surprising information on regulation of osteoblast and osteoclast function.
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Raisz, L.G. (1999). Understanding and Manipulating Genes, Hormones and Bone Cells. In: Adams, J.S., Lukert, B.P. (eds) Osteoporosis: Genetics, Prevention and Treatment. Endocrine Updates, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5115-7_17
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DOI: https://doi.org/10.1007/978-1-4615-5115-7_17
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