Abstract
The intracellular esterification of sterols by all eukaryotes represents a critical homeostatic response to excess sterol. This process is mediated by a multigene family in several organisms, including the unicellular eukaryote, Saccharomyces cerevisiae (yeast). We describe here our recent efforts to identify molecular components of sterol esterification and sterol transport in this model system. This includes homologs to the acyl-CoA cholesterol acyl transferase (ACAT) gene, a putative homolog to the Niemann Pick C (NPC) gene, and novel yeast genes with human counterparts.
All authors contributed equally to this paper.
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Oelkers, P., Sturley, S.L., Tinkelenberg, A. (1998). Sterol Esterification and Homeostasis in a Model Eukaryote. In: Chang, T.Y., Freeman, D.A. (eds) Intracellular Cholesterol Trafficking. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5113-3_4
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DOI: https://doi.org/10.1007/978-1-4615-5113-3_4
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